CRYSTAL STRUCTURE OF THE HUMAB PIM1 IN COMPLEX WITH LY333531
PDB id Source Resolution
2J2I 1.9 angstroms
Ligand Information
Ligand Validity Binding
Data		 Ligand
Warnings		 Eolus Viewer
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Viewer		 Molecular
Weight
(Da)		 Formula SMILES
LY4 Valid ic50 =  0.2 uM More atoms than expected were found for ligand in PDB. % Diff = 2.0  launch gocavviewer-lite   468.547
C28 H28 N4 O3
 CN(C)C[C@@H]1CCn2cc(c3c2cccc3)C4=C(c5cn(c6c5cccc6)CCO1)C(=O)NC4=O
SO4 Invalid            

A SYSTEMATIC INTERACTION MAP OF VALIDATED KINASE IN WITH SER/THR KINASES. PROC.NATL.ACAD.SCI.USA V. 104 20523 2007

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90% Homology Family

The Class containing this family consists of a total of 56 families.
Leader:    3BWF
CRYSTAL STRUCTURE OF THE HUMAN PIM1 IN COMPLEX
WITH AN OSMIUM COMPOUND
PDB id Binding data Representative ligand
3BWF ic50 = 0.6 nM DWC
1XR1   ANP
1XWS   BI1
1YHS ic50 = 0.01 uM STO
1YI3 ic50 = 4.0 uM LY2
1YI4   ADN
1YXU   AMP
1YXV   LI6
1YXX   LI7
2BIK   BI1
2C3I Kd = 25.0 nM IYZ
2J2I ic50 = 0.2 uM LY4
2O3P ic50 = 1.1 uM QUE
2O63 Kd = 0.78 uM MYC
2O64 Kd = 0.34 uM MYU
2OBJ ic50 = 0.05 uM VRV
2OI4 ic50 = 2.5 nM JM1
2XIX   XIX
2XIY   XIY
2XIZ   XIZ
2XJ1 Kd = 28.0 nM XJ1
2XJ2 Kd = 66.0 nM 985
3A99   ANP
3BGQ Ki = 11.0 nM VX2
3BGZ Ki = 0.55 uM VX3
3C4E ic50 ~ 100.0 uM C4E
3F2A ic50 = 57.0 nM 985
3MA3 ic50 = 60.0 nM 01I
3R00 ic50 = 8.5 uM UNJ
3R02 ic50 = 0.0010 uM UNM
3R04 ic50 = 0.12 uM UNQ