CRYSTAL STRUCTURE OF CHECKPOINT KINASE 2 IN COMPLEX WITH INH PV1115
PDB id Source Resolution
2YCQ 2.05 angstroms
Ligand Information
Ligand Validity Binding
Data		 Ligand
Warnings		 Eolus Viewer
(click picture
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Viewer		 Molecular
Weight
(Da)		 Formula SMILES
UPX Valid ic50 =  0.14 nM   launch gocavviewer-lite   403.394
C20 H17 N7 O3
 C/C(=NNc1[nH]ccn1)/c2ccc(cc2)NC(=O)c3cc4cccc(c4[nH]3)[N+](=O)[O-]
NO3 Invalid            

STRUCTURAL CHARACTERIZATION OF INHIBITOR COMPLEXES CHECKPOINT KINASE 2 (CHK2), A DRUG TARGET FOR CANCE THERAPY. J.STRUCT.BIOL. V. 176 292 2011

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90% Homology Family

The Class containing this family consists of a total of 56 families.
Leader:    2YCQ
CRYSTAL STRUCTURE OF CHECKPOINT KINASE 2 IN COMPLEX
WITH INH PV1115
PDB id Binding data Representative ligand
2YCQ ic50 = 0.14 nM UPX
2CN5   ADP
2W0J ic50 = 240.0 nM ZAT
2W7X ic50 = 138.0 nM D1A
2WTI ic50 = 0.092 uM WTI
2WTJ ic50 = 0.7 uM WTJ
2XBJ ic50 = 0.86 uM XBJ
2XK9 ic50 = 0.03 nM XK9
2XM9 ic50 = 0.0090 uM LWH
2YCF ic50 = 0.7 nM YCF
2YCR ic50 = 69.6 nM HCW
2YCS ic50 = 1.36 nM NXP
2YIQ ic50 = 12.67 nM YIQ
2YIR ic50 = 0.17 nM YIR
2YIT ic50 = 0.29 nM YIT