EGFR KINASE DOMAIN COMPLEXED WITH TAK-285
PDB id Source Resolution
3POZ 1.5 angstroms
Ligand Information
Ligand Validity Binding
Data		 Ligand
Warnings		 Eolus Viewer
(click picture
to launch)		 Chemaxon
Viewer		 Molecular
Weight
(Da)		 Formula SMILES
03P Valid ic50 =  23.0 nM   launch gocavviewer-lite   547.957
C26 H25 Cl F3 N5 O3
 CC(C)(CC(=O)NCCn1ccc2c1c(ncn2)Nc3ccc(c(c3)Cl)Oc4cccc(c4)C(F)(F)F)O
SO4 Invalid            

STRUCTURAL ANALYSIS OF THE MECHANISM OF INHIBITION ALLOSTERIC ACTIVATION OF THE KINASE DOMAIN OF HER2 J.BIOL.CHEM. V. 286 18756 2011

More Information
External References
PDB
Pubmed
Biounit Downloads
This PDB
This Family
This Class
Comma Separated Files
This PDB
This Family
This Class
Download BindingMOAD
90% Homology Family

The Class containing this family consists of a total of 27 families.
Leader:    1XKK
EGFR KINASE DOMAIN COMPLEXED WITH A QUINAZOLINE
INHIBITOR- GW572016
PDB id Binding data Representative ligand
1XKK Ki = 3.0 nM FMM
2ITN   ANP
2ITV   ANP
2RGP ic50 = 0.3 uM HYZ
3BEL ic50 = 0.014 uM POX
3POZ ic50 = 23.0 nM 03P