CRYSTAL STRUCTURE OF THE KINASE DOMAIN OF HUMAN HER2 (ERBB2)
PDB id Source Resolution
3PP0 2.25 angstroms
Ligand Information
Ligand Validity Binding
Data		 Ligand
Warnings		 Eolus Viewer
(click picture
to launch)		 Chemaxon
Viewer		 Molecular
Weight
(Da)		 Formula SMILES
03Q Valid ic50 =  11.0 nM   launch gocavviewer-lite   493.866
C22 H19 Cl F3 N5 O3
 c1cc(cc(c1)Oc2c(cc(cn2)Nc3c4c(ccn4CCOCCO)ncn3)Cl)C(F)(F)F

STRUCTURAL ANALYSIS OF THE MECHANISM OF INHIBITION ALLOSTERIC ACTIVATION OF THE KINASE DOMAIN OF HER2 J.BIOL.CHEM. V. 286 18756 2011

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90% Homology Family

The Class containing this family consists of a total of 27 families.
Leader:    3PP0
CRYSTAL STRUCTURE OF THE KINASE DOMAIN OF HUMAN
HER2 (ERBB2)