THYMIDINE KINASE, DHBT
PDB id Source Resolution
1E2P HERPES SIMPLEX VIRUS TYPE 1 2.5 angstroms
Ligand Information
Ligand Validity Binding
Data		 Ligand
Warnings		 Eolus Viewer
(click picture
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Viewer		 Molecular
Weight
(Da)		 Formula SMILES
CCV Valid Ki =  27.0 uM   launch gocavviewer-lite   214.218
C9 H14 N2 O4
 CC1=C(NC(=O)NC1=O)CC(CO)CO
SO4 Invalid            

THE EFFECT OF SUBSTRATE BINDING ON THE CONFORMATION AND STRUCTURAL STABILITY OF HERPES SIMPLEX VIRUS TYPE 1 THYMIDINE KINASE PROTEIN SCI. V. 10 63 2001

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90% Homology Family

The Class containing this family consists of a total of 7 families.
Leader:    1E2K
KINETICS AND CRYSTAL STRUCTURE OF THE WILD-TYPE
AND THE ENGINEERED Y101F MUTANT OF HERPES SIMPLEX
VIRUS TYPE 1 T HYMIDINE KINASE INTERACTING
WITH (N ORTH)-METHANOCARBA
-THYMIDINE
PDB id Binding data Representative ligand
1E2K Ki = 11.4 uM TMC
1E2I   ARP
1E2J   THM
1E2L Ki = 51.5 uM TMC
1E2M   HPT
1E2N Ki = 30.9 uM RCA
1E2P Ki = 27.0 uM CCV
1KI2   GA2
1KI3   PE2
1KI4   BTD
1KI6   AHU
1KI7   ID2
1KI8   BVD
1KIM   THM
1OF1 ic50 = 15.0 uM SCT
1P7C   THM
1QHI   BPG
2KI5   AC2
3F0T   NCV