PLASMODIUM FALCIPARUM LACTATE DEHYDROGENASE COMPLEXED WITH N HYDROXY-1,2,5-THIADIAZOLE-3-CARBOXYLIC ACID
PDB id Source Resolution
1T26 PLASMODIUM FALCIPARUM 1.8 angstroms
Ligand Information
Ligand Validity Binding
Data		 Ligand
Warnings		 Eolus Viewer
(click picture
to launch)		 Chemaxon
Viewer		 Molecular
Weight
(Da)		 Formula SMILES
GBD Valid ic50 =  0.14 uM   launch gocavviewer-lite   146.125
C3 H2 N2 O3 S
 c1(c(nsn1)O)C(=O)O
NAI Valid submit data   launch gocavviewer-lite   665.441
C21 H29 N7 O14 P2
 c1nc(c2c(n1)n(cn2)[C@H]3[C@@H]([C@@H]([C@H](O3)CO[P@](=O)(O)O[P@@](=O)(O)OC[C@@H]4[C@H]([C@H]([C@@H](O4)N5C=CCC(=C5)C(=O)N)O)O)O)O)N

IDENTIFICATION AND ACTIVITY OF A SERIES OF AZOLE-BA COMPOUNDS WITH LACTATE DEHYDROGENASE-DIRECTED ANTI-ACTIVITY. J.BIOL.CHEM. V. 279 31429 2004

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90% Homology Family

The Class containing this family consists of a total of 16 families.
Leader:    1T26
PLASMODIUM FALCIPARUM LACTATE DEHYDROGENASE COMPLEXED
WITH N HYDROXY-1,2,5-THIADIAZOLE-3-CARBOXYLIC ACID
PDB id Binding data Representative ligand
1T26 ic50 = 0.14 uM GBD
1CET Ki = 1.3 mM CLQ
1LDG   OXM
1OC4   OXM
1T24 ic50 = 0.65 uM OXQ
1T25 ic50 = 1.1 uM GAG
1T2C   NAI
1T2D   NAD
1T2E   OXM
1U4O   NDD
1U4S   BIH
1U5A   BIK
1XIV   RB2
2A94   AP0