TRYPANOSOMA BRUCEI DIHYDROFOLATE REDUCTASE PYRIMETHAMINE COM
PDB id Source Resolution
3QFX 2.2 angstroms
Ligand Information
Ligand Validity Binding
Data		 Ligand
Warnings		 Eolus Viewer
(click picture
to launch)		 Chemaxon
Viewer		 Molecular
Weight
(Da)		 Formula SMILES
NDP Valid submit data   launch gocavviewer-lite   745.421
C21 H30 N7 O17 P3
 c1nc(c2c(n1)n(cn2)[C@H]3[C@@H]([C@@H]([C@H](O3)CO[P@](=O)(O)O[P@@](=O)(O)OC[C@@H]4[C@H]([C@H]([C@@H](O4)N5C=CCC(=C5)C(=O)N)O)O)O)OP(=O)(O)O)N
CP6 Valid Ki =  24.2 nM   launch gocavviewer-lite   248.711
C12 H13 Cl N4
 CCc1c(c(nc(n1)N)N)c2ccc(cc2)Cl

TRYPANOSOMAL DIHYDROFOLATE REDUCTASE REVEALS NATURA ANTIFOLATE RESISTANCE ACS CHEM.BIOL. 2011

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90% Homology Family

The Class containing this family consists of a total of 22 families.
Leader:    3RG9
TRYPANOSOMA BRUCEI DIHYDROFOLATE REDUCTASE (TBDHFR
) IN COMPL WR99210
PDB id Binding data Representative ligand
3RG9 Ki = 1.1 nM WRA
3QFX Ki = 24.2 nM CP6