FACTOR INHIBITING HIF-1 ALPHA IN COMPLEX WITH R-2-HYDROXYGLU
PDB id Source Resolution
2YC0 2.15 angstroms
Ligand Information
Ligand Validity Binding
Data		 Ligand
Warnings		 Eolus Viewer
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Viewer		 Molecular
Weight
(Da)		 Formula SMILES
2HG Valid ic50 =  1500.0 uM   launch gocavviewer-lite   148.114
C5 H8 O5
 C(CC(=O)O)[C@H](C(=O)O)O
GOL Invalid            
SO4 Invalid            

THE ONCOMETABOLITE 2-HYDROXYGLUTARATE INHIBITS HISTONE LYSINE DEMETHYLASES. EMBO REP. V. 12 463 2011

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90% Homology Family

The Class containing this family consists of a total of 7 families.
Leader:    2WA4
FACTOR INHIBITING HIF-1 ALPHA WITH N,3-DIHYDROXYBENZAMIDE
PDB id Binding data Representative ligand
2WA4 ic50 = 18.0 uM 069
1MZE   TAR
1MZF   AKG
2CGN   SIN
2W0X ic50 = 625.0 uM PD2
2WA3 ic50 = 1.0 mM A29
2YC0 ic50 = 1500.0 uM 2HG
2YDE ic50 = 189.0 uM S2G