CRYSTAL STRUCTURE OF HIV-1 REVERSE TRANSCRIPTASE (RT) IN COM R221239
PDB id Source Resolution
2BE2 2.43 angstroms
Ligand Information
Ligand Validity Binding
Data		 Ligand
Warnings		 Eolus Viewer
(click picture
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Viewer		 Molecular
Weight
(Da)		 Formula SMILES
SUC Invalid            
GOL Invalid            
R22 Valid ic50 =  0.0020 uM   launch gocavviewer-lite   481.347
C20 H20 I N O3 S
 Cc1cc(cc(c1)OC2=C(C(=O)NC(=C2CSCc3ccco3)C)I)C

CRYSTAL STRUCTURES FOR HIV-1 REVERSE TRANSCRIPTASE COMPLEXES WITH THREE PYRIDINONE DERIVATIVES: A NEW NON-NUCLEOSIDE INHIBITORS EFFECTIVE AGAINST A BROAD DRUG-RESISTANT STRAINS. J.MED.CHEM. V. 48 7582 2005

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90% Homology Family

The Class containing this family consists of a total of 4 families.
Leader:    3DLG
CRYSTAL STRUCTURE OF HIV-1 REVERSE TRANSCRIPTASE
IN COMPLEX WITH GW564511.
PDB id Binding data Representative ligand
3DLG ic50 = 1.2 nM GWE
1C1B   GCA
1C1C   612
1EP4   S11
1FK9   EFZ
1JKH   EFZ
1JLA   TNK
1RTH ic50 = 0.4 uM U05
1S1T   UC1
1VRT ic50 = 0.08 uM NEV
1VRU ic50 = 0.1 uM AAP
2BE2 ic50 = 0.0020 uM R22
2HND   NVP
2HNY ic50 = 1165.0 nM NVP
2IAJ   ATP
2OPS   HBQ
2RF2 ic50 = 3.6 nM MRX
2RKI   TT1
2YKN   YKN
2ZD1   T27
3BGR   T27
3DLE ic50 = 2.0 nM GFA
3DOL   GWI
3DYA ic50 = 3.0 nM PZL
3ISN Ki = 8.0 nM EDM
3LP1   LP8
3MEC   65B
3MED   65B
3MEE   T27
3QIP   P4Y