1.- Oxidoreductases
2.- Transferases
3.- Hydrolases
4.- Lyases
5.- Isomerases
6.- Ligases
Unclassified Enzymes

Binding
Folding Proteins
Immunological Proteins
Mobility/Motility
Other
Toxins/Viral Proteins
Transcription/Translation
Transport
Cell Cycle
Signal Hormone
Structural

FOLDING

Families belonging to this class:

90% Homology Family
Leader: 2VCI
4,5 DIARYL ISOXAZOLE HSP90 CHAPERONE INHIBITORS: POTENTIAL
PDB id Binding data Representative ligand
2VCI ic50 = 0.021 uM 2GJ
1BYQ   ADP
1OSF   KOS
1UY6 IC50 > 200.0 uM PU3
1UY7 IC50 > 200.0 uM PU4
1UY8 IC50 = 75.0 uM PU5
1UY9 IC50 = 15.3 uM PU6
1UYC IC50 = 41.0 uM PU7
1UYD IC50 > 200.0 uM PU8
1UYE IC50 > 200.0 uM PU9
1UYF IC50 = 30.0 uM PU1
1UYG IC50 = 53.5 uM PU2
1UYH IC50 = 14.3 uM PU0
1UYI IC50 = 4.1 uM PUZ
1UYK IC50 = 17.1 uM PUX
1YET   GDM
2BSM IC50 = 1.5 uM BSM
2BT0 IC50 = 5.7 uM CT5
2BYH IC50 = 0.258 uM 2D7
2BYI IC50 = 0.461 uM 2DD
2CCS IC50 = 8.2 uM 4BH
2CCT IC50 = 6.3 uM 2E1
2CDD IC50 = 0.148 uM CT5
2FWY IC50 = 200.0 nM H64
2FWZ IC50 = 50.0 nM H71
2H55   DZ8
2JJC   LGA
2QFO Ki = 18.0 uM A13
2QG0 Ki = 1.9 uM A94
2QG2 Ki = 4.0 uM A91
2VCJ ic50 = 0.021 uM 2EQ
3BM9 ic50 = 0.19 uM BXZ
3BMY ic50 = 0.03 uM CXZ
3D0B Kd = 0.29 uM SNX
3EKO Ki = 0.2 uM PYU
3EKR Ki = 2.8 uM PY9
90% Homology Family
Leader: 1BGQ
RADICICOL BOUND TO THE ATP BINDING SITE OF THE
N-TERMINAL DOMAIN OF THE YEAST HSP90 CHAPERONE
PDB id Binding data Representative ligand
1BGQ kd = 2.7 nM RDC
1A4H   GMY
1AM1 kd = 132.0 mM ADP
1AMW kd = 29.0 mM ADP
2BRC IC50 = 7.1 uM CT5
2BRE IC50 < 1.0 uM KJ2
2CGF Kd = 0.39 uM P2N
2IWX Kd = 0.21 uM M1S
2VW5 Ki = 3.0 nM BC6
2VWC Ki = 0.24 uM BC2
90% Homology Family
Leader: 1U0Z
N-DOMAIN OF GRP94 LACKING THE CHARGED DOMAIN IN COMPLEX
PDB id Binding data Representative ligand
1U0Z   RDC
1TBW   AMP
1TC0   ATP
1TC6   ADP
1U2O   NEC
1YT0   ADP
90% Homology Family
Leader: 1QY5
CRYSTAL STRUCTURE OF THE N-DOMAIN OF THE ER HSP90 CHAPERONE
PDB id