1.- Oxidoreductases
2.- Transferases
3.- Hydrolases
4.- Lyases
5.- Isomerases
6.- Ligases
Unclassified Enzymes

Binding
Folding Proteins
Immunological Proteins
Mobility/Motility
Other
Toxins/Viral Proteins
Transcription/Translation
Transport
Cell Cycle
Signal Hormone
Structural

SIGNAL_HORMONE

Families belonging to this class:

90% Homology Family
Leader: 1M5B
X-RAY STRUCTURE OF THE GLUR2 LIGAND BINDING CORE
(S1S2J) IN COMPLEX WITH 2-ME-TET-AMPA AT 1.85 A RESOLUTION.
PDB id Binding data Representative ligand
1M5B IC50 = 9.7 nM BN1
1FTJ IC50 = 821.0 nM GLU
1FTK IC50 = 14.5 uM KAI
1FTL IC50 = 998.0 nM DNQ
1FTM kd = 24.8 nM AMQ
1FW0   KAI
1GR2   KAI
1LB8   AMQ
1LB9   DNQ
1LBB   KAI
1LBC   CYZ
1M5C IC50 = 0.5 uM BRH
1M5D IC50 = 9.2 uM BRH
1M5E IC50 = 20.1 nM AM1
1M5F IC50 = 14.8 nM AM1
1MM6 IC50 = 20.0 nM QUS
1MM7 IC50 = 20.0 nM QUS
1MQD IC50 = 0.17 uM SHI
1MQG IC50 = 0.52 uM IWD
1MQH IC50 = 0.3 uM BWD
1MQI IC50 = 23.53 nM FWD
1MQJ IC50 = 4.76 uM HWD
1MS7 IC50 = 0.17 uM SHI
1MXU IC50 = 4.0 uM BWD
1MY2   AMQ
1MY3   BWD
1MY4   IWD
1N0T IC50 = 16.0 uM AT1
1NNK IC50 = 3.5 uM CE2
1NNP   CE2
1P1N kd = 0.16 uM KAI
1P1O kd = 1.74 uM QUS
1P1Q kd = 12.8 uM AMQ
1P1U   AMQ
1P1W   AMQ
1SYH Ki = 393.0 nM CPW
1SYI Ki = 3330.0 nM CPW
1WVJ Ki = 185.0 nM IBC
1XHY ki = 624.0 nM KAI
2AIX   U1K
2AL4   QUS
2AL5   FWD
2ANJ   KAI
2GFE   GLU
2I3V   GLU
2I3W   GLU
2P2A Ki = 0.75 uM MP9
3B6Q   GLU
3B6T   QUS
3B6W   GLU
3B7D   CNI
3BBR   BHY
3BFT Ki = 323.0 nM S2P
3BFU Ki = 531.0 nM R2P
3BKI ic50 = 7.6 uM FQX
3DP6   GLU
90% Homology Family
Leader: 2AX9
CRYSTAL STRUCTURE OF THE ANDROGEN RECEPTOR LIGAND
BINDING DOMAIN IN COMPLEX WITH R-3
PDB id Binding data Representative ligand
2AX9 Ki = 0.3 nM BHM
1E3G   R18
1GS4   ZK5
1I37   DHT
1I38   DHT
1T7T   DHT
1XNN Ki = 0.5 nM HYQ
1XOW   R18
1XQ3   R18
1Z95 Ki = 76.0 ? 198
2AM9   TES
2AMA   DHT
2AMB   17H
2AX6   HFT
2AX7   FHM
2AX8   FHM
2AXA Ki = 6.1 nM FHM
2HVC   LGD
2IHQ Ki = 3.2 nM LG7
2OZ7   CA4
2PIO   DHT
2PIP   DHT
2PIQ   DHT
2PIR   DHT
2PIT   DHT
2PIU   DHT
2PIV   DHT
2PIX   DHT
2PKL   DHT
2PNU   ENM
2Q7I   TES
2Q7K   TES
2QPY   DHT
3B5R   B5R
3B65   3B6
3B66   B66
3B67   B67
3B68   B68
90% Homology Family
Leader: 2OMH
STRUCTURE OF HUMAN INSULIN COCRYSTALLIZED WITH ARG-12
PDB id Binding data Representative ligand
2OMH   RCO
1BEN   HBD
1EV3   CRS
1EV6   CRS
1EVR   RCO
1LPH   IPH
1MPJ   IPH
1Q4V   IPH
1QIY   IPH
1QIZ   RCO
1TYL   TYL
1TYM   TYL
1UZ9   CRS
1WAV   IPH
1ZEG   IPH
1ZEH   CRS
1ZNJ   IPH
2OLY   RCO
2OLZ   RCO
2OMG   CRS
2OMI   RCO
90% Homology Family
Leader: 2PBW
CRYSTAL STRUCTURE OF THE LIGAND-BINDING CORE OF IGLUR5 IN
PDB id Binding data Representative ligand
2PBW Ki = 5.56 nM DOQ
1TXF Ki = 57.2 nM GLU
1VSO Ki = 18980.0 nM AT1
1YCJ   GLU
2F34 Kd = 0.13 uM UBA
2F35 Kd = 3.94 uM UBC
2F36   GLU
2OJT   UBA
3C31   KAI
3C32   KAI
3C33   KAI
3C34   KAI
3C35   KAI
3C36   KAI
90% Homology Family
Leader: 1N46
CRYSTAL STRUCTURE OF HUMAN TR BETA LIGAND-BINDING
DOMAIN COMPLEXED WITH A POTENT SUBTYPE-SELECTIVE
THYROMIMETIC
PDB id Binding data Representative ligand
1N46 ki = 0.03 nM PFA
1NQ0   4HY
1NQ2   4HY
1XZX Kd = 0.06 nM T3
2H6W   T3
2J4A   OEF
2PIN   4HY
3D57   4HY
90% Homology Family
Leader: 1GT4
COMPLEX OF BOVINE ODORANT BINDING PROTEIN WITH UNDECANAL
PDB id Binding data Representative ligand
1GT4 Kd = 0.3 uM UNA
1G85 kd = 3.3 uM 3OL
1GT1 Kd = 1.2 uM 3OL
1GT3 Kd = 1.2 uM 3OL
1GT5 Kd = 0.8 uM BZQ
1HN2 kd = 3.3 uM 3OL
1PBO   SES
2HLV   LIK
90% Homology Family
Leader: 1DZK
PORCINE ODORANT BINDING PROTEIN COMPLEXED WITH
PYRAZINE (2-ISOBUTYL-3-METOXYPYRAZINE)
PDB id Binding data Representative ligand
1DZK kd = 0.8 uM PRZ
1DZJ IC50 = 1.3 uM SES
1DZM IC50 = 3.9 uM BZM
1DZP IC50 = 3.6 uM BZQ
1E00 IC50 = 0.8 uM DHM
1E02 IC50 = 0.7 uM UNA
1E06 IC50 = 2.5 uM IPB
1HQP   PRZ
90% Homology Family
Leader: 1PBQ
CRYSTAL STRUCTURE OF THE NR1 LIGAND BINDING CORE
IN COMPLEX WITH 5,7-DICHLOROKYNURENIC ACID (
DCKA) AT 1.90 ANGSTROMS RESOLUTION
PDB id Binding data Representative ligand
1PBQ ki = 0.54 uM DK1
1PB7   GLY
1PB8 ki = 7.02 uM DSN
1PB9 ki = 241.0 uM 4AX
1Y1M Ki = 15.3 mM AC5
1Y1Z Ki = 0.831 mM 192
1Y20 Ki = 4.8 uM 1AC
90% Homology Family
Leader: 2ZMI
CRYSTAL STRUCTURE OF RAT VITAMIN D RECEPTOR BOUND TO
PDB id Binding data Representative ligand
2ZMI ic50 = 3.0 nM TT2
2ZL9   VDA
2ZLA   VDB
2ZLC   VDX
2ZMH   NYA
2ZMJ ic50 = 30.0 nM MI4
90% Homology Family
Leader: 1M6P
EXTRACYTOPLASMIC DOMAIN OF BOVINE CATION-DEPENDENT
MANNOSE 6-PHOSPHATE RECEPTOR
PDB id Binding data Representative ligand
1M6P kd = 8.0 uM M6P
1C39   P3M
2RL8   M6D
2RL9   M6P-MAN-MAN
2RLB   M6D
90% Homology Family
Leader: 2O4J
CRYSTAL STRUCTURE OF RAT VITAMIN D RECEPTOR LIGAND BINDING
PDB id Binding data Representative ligand
2O4J Ki = 0.08 nM VD4
1RJK   VDZ
1RK3 Kd = 0.37 nM VDX
1RKG   VD1
1RKH   VD2
2O4R Kd = 0.4 nM VD5
90% Homology Family
Leader: 2DT3
CRYSTAL STRUCTURE OF THE COMPLEX FORMED BETWEEN GOAT
PDB id Binding data Representative ligand
2DT3 Kd = 18.0 uM NAG-NAG-NAG-NAG-NAG-NAG
1ZB5   TRP-PRO-TRP
1ZBC   TRP-PRO-TRP
2DSU   NDG-NAG-NAG-NAG
2DT0   NAG-NAG-NAG
2DT1   NAG-NAG-NAG-NAG
90% Homology Family
Leader: 1JYQ
XRAY STRUCTURE OF GRB2 SH2 DOMAIN COMPLEXED WITH
A HIGHLY AFFINE PHOSPHO PEPTIDE
PDB id Binding data Representative ligand
1JYQ kd = 2.5 nM MAZ-PTR-PTM-ASN
1JYR kd = 18.0 nM ALA-PRO-SER-PTR-VAL-ASN-VAL-GLN-ASN
1TZE IC50 = 148.0 nM LYS-PRO-PHE-PTR-VAL-ASN-VAL-NH2
1ZFP IC50 = 26.0 nM BE2-GLU-PTR-ILE-ASN-GLN-NH2
2AOA   S1S
2AOB   S1S
90% Homology Family
Leader: 1JPN
GMPPNP COMPLEX OF SRP GTPASE NG DOMAIN
PDB id Binding data Representative ligand
1JPN   GNP
1JPJ   GNP
1NG1   GDP
1O87   GDP
2NG1   GDP
90% Homology Family
Leader: 2BYS
CRYSTAL STRUCTURE OF ACHBP FROM APLYSIA CALIFORNICA IN
PDB id Binding data Representative ligand
2BYS Kd = 0.3 nM LOB
2BYR Kd = 2.8 nM MLK
2PGZ Kd = 1.8 uM COC
3C79 Kd = 63.0 nM IM4
3C84 Kd = 14.0 nM TH4
90% Homology Family
Leader: 2AG4
CRYSTAL STRUCTURE ANALYSIS OF GM2-ACTIVATOR PROTEIN
COMPLEXED WITH PHOSPHATIDYLCHOLINE
PDB id Binding data Representative ligand
2AG4   LP3
1TJJ   PFS
2AF9   MYR
2AG2   CH5
2AG9   MYR
90% Homology Family
Leader: 1W9O
CRYSTAL STRUCTURE OF THE PDZ TANDEM OF HUMAN
SYNTENIN IN COMPLEX WITH TNEYYV PEPTIDE
PDB id Binding data Representative ligand
1W9O Kd = 0.74 mM THR-ASN-GLU-TYR-TYR-VAL
1OBZ   GLU-THR-LEU-GLU-ASP-SER-VAL-PHE
1V1T   THR-ASN-GLU-TYR-LYS-VAL
1W9E Kd = 1.0 mM THR-ASN-GLU-PHE-TYR-PHE
1W9Q   THR-ASN-GLU-PHE-ALA-PHE
90% Homology Family
Leader: 1TT1
CRYSTAL STRUCTURE OF THE GLUR6 LIGAND BINDING CORE IN
PDB id Binding data Representative ligand
1TT1 Ki = 64.6 nM KAI
1S50 Ki = 1.4 uM GLU
1S7Y Ki = 1.4 uM GLU
1S9T Ki = 253.0 nM QUS
1SD3   SYM
90% Homology Family
Leader: 1D01
STRUCTURE OF TNF RECEPTOR ASSOCIATED FACTOR 2 IN COMPLEX
PDB id Binding data Representative ligand
1D01   ACE-MET-LEU-SER-VAL-GLU-GLU-GLU-GLY
1CZY   ACE-PRO-GLN-GLN-ALA-THR-ASP-ASP
1D00   ACE-PRO-VAL-GLN-GLU-THR-NH2
1D0A   ACE-PRO-ILE-GLN-GLU-GLU
1D0J   ACE-GLY-ALA-ALA-GLN-GLU-GLU
90% Homology Family
Leader: 1BM2
GRB2-SH2 DOMAIN IN COMPLEX WITH CYCLO-[N-ALPHA
-ACETYL-L-THI ALYSYL-O-PHOSPHOTYROSYL-VALYL-ASPARAGYL
-VALYL-PROLYL] (PKF273-791)
PDB id Binding data Representative ligand
1BM2 IC50 = 0.11 uM ACE-SLZ-PTR-VAL-ASN-VAL-PRO
1BMB IC50 = 0.7 uM LYS-PRO-PHE-PTR-VAL-ASN-VAL-GLU-PHE
1FYR IC50 = 2.4 uM ACE-PTR-VAL-ASN-VAL
2HUW Ka = 1000000.0 M^-1 YVN
3C7I Ka = 440000.0 M^-1 TVN
90% Homology Family
Leader: 3CV0
STRUCTURE OF PEROXISOMAL TARGETING SIGNAL 1 (PTS1) BINDING
PDB id Binding data Representative ligand
3CV0   PHE-ASN-GLU-LEU-SER-HIS-LEU
3CVL   HIS-GLU-GLU-LEU-ALA-LYS-LEU
3CVN   ARG-ASP-ARG-ALA-ALA-LYS-LEU
3CVP   GLY-THR-LEU-SER-ASN-ARG-ALA-SER-LYS-LEU
90% Homology Family
Leader: 2HRL
SIGLEC-7 IN COMPLEX WITH GT1B
PDB id Binding data Representative ligand
2HRL IC50 = 0.26 mM SIA-GAL-SIA-GLC-NGA-CEQ
1O7S   NDG
2DF3   SIA-NAG-GAL-SIA
2G5R   NXD
90% Homology Family
Leader: 1RJ9
STRUCTURE OF THE HETERODIMER OF THE CONSERVED GTPASE
PDB id Binding data Representative ligand
1RJ9   GCP
1OKK   GCP
2CNW   5GP
2J7P   GNP
90% Homology Family
Leader: 2V7D
14-3-3 PROTEIN ZETA IN COMPLEX WITH THR758 PHOSPHORYLATED
PDB id Binding data Representative ligand
2V7D Kd = 261.0 nM LYS-SER-ALA-TPO-THR-THR-VAL-MET-ASN-PRO
1QJA ki = 416.0 nM ARG-LEU-TYR-HIS-SEP-LEU-PRO-ALA
1QJB ki = 416.0 nM ARG-SER-HIS-SEP-TYR-PRO-ALA
2C1N   ALA-ARG-LYS-SEP-THR-GLY-GLY-LYS
90% Homology Family
Leader: 1Y2F
CRYSTAL STRUCTURE OF ZIPA WITH AN INHIBITOR
PDB id Binding data Representative ligand
1Y2F Kd = 12.0 uM WAI
1S1J   IQZ
1S1S   WAC
1Y2G Kd = 83.1 uM CL3
90% Homology Family
Leader: 1PQ9
HUMAN LXR BETA HORMONE RECEPTOR COMPLEXED WITH T0901317
PDB id Binding data Representative ligand
1PQ9   BNS
1PQ6   965
1UPV   444
1UPW   444
90% Homology Family
Leader: 1OT6
CRYOTRAPPED CRYSTAL STRUCTURE OF THE E46Q MUTANT OF
PDB id Binding data Representative ligand
1OT6   HC4
1OT9   HC4
1UWP   HC4
2QJ7   HC4
90% Homology Family
Leader: 1SR7
PROGESTERONE RECEPTOR HORMONE BINDING DOMAIN WITH BOUND
PDB id Binding data Representative ligand
1SR7 Kd = 0.08 nM MOF
1A28   STR
1SQN Kd = 0.4 nM NDR
1ZUC IC50 = 1.7 nM T98
90% Homology Family
Leader: 1SEM
STRUCTURAL DETERMINANTS OF PEPTIDE-BINDING ORIENTATION
AND OF SEQUENCE SPECIFICITY IN SH3 DOMAINS
PDB id Binding data Representative ligand
1SEM kd = 43.0 uM ACE-PRO-PRO-PRO-VAL-PRO-PRO-ARG-ARG-ARG
2SEM   ACE-PRO-PRO-PRO-VAL-IPG-PRO-ARG-ARG
3SEM   PRO-PRO-PRO-VAL-NMC-PRO-ARG-ARG-ARG
90% Homology Family
Leader: 2VCO
CRYSTAL STRUCTURE OF THE FIMBRIAL ADHESIN FIMH IN COMPLEX
PDB id Binding data Representative ligand
2VCO Kd = 20.0 nM MAN-MAN-NAG-MAN-NAG
1TR7 Kd = 0.15 uM DEG
1UWF Kd = 0.15 uM DEG
90% Homology Family
Leader: 2RC8
CRYSTAL STRUCTURE OF THE NR3A LIGAND BINDING CORE COMPLEX
PDB id Binding data Representative ligand
2RC8   DSN
2RC7   GLY
2RC9   1AC
90% Homology Family
Leader: 2Q7J
THE WILD TYPE ANDROGEN RECEPTOR LIGAND BINDING DOMAIN BOUND
PDB id Binding data Representative ligand
2Q7J   TES
1T63   DHT
2Q7L   TES
90% Homology Family
Leader: 2Q1H
ANCESTRAL CORTICOID RECEPTOR IN COMPLEX WITH ALDOSTERONE
PDB id Binding data Representative ligand
2Q1H   AS4
2Q1V   PDN
2Q3Y   PRO-ALA-ILE-LEU-TYR-ALA-LEU-LEU-SER-SER
90% Homology Family
Leader: 2E4U
CRYSTAL STRUCTURE OF THE EXTRACELLULAR REGION OF THE GROUP
PDB id Binding data Representative ligand
2E4U   GLU
2E4V   2CG
2E4W   C5A
90% Homology Family
Leader: 1U8Z
CRYSTAL STRUCTURES OF RAL-GPPNHP AND RAL-GDP REVEAL TWO
PDB id Binding data Representative ligand
1U8Z   GDP
1U8Y   GNP
1U90   GDP
90% Homology Family
Leader: 1NTV
CRYSTAL STRUCTURE OF THE DISABLED-1 (DAB1) PTB
DOMAIN-APOER2 PEPTIDE COMPLEX
PDB id Binding data Representative ligand
1NTV   ASN-PHE-ASP-ASN-PRO-VAL-TYR-ARG-LYS-THR
1NU2   ASN-PHE-ASP-ASN-PRO-VAL-TYR-ARG-LYS-THR
1OQN   I3P
90% Homology Family
Leader: 2H79
CRYSTAL STRUCTURE OF HUMAN TR ALPHA BOUND T3
IN ORTHORHOMBIC SPACE GROUP
PDB id Binding data Representative ligand
2H79   T3
1NAV   IH5
2H77   T3
90% Homology Family
Leader: 1FWV
CRYSTAL STRUCTURE OF THE CYSTEINE-RICH DOMAIN
OF MANNOSE RECEPTOR COMPLEXED WITH 3-SO4-LEWIS(A)
PDB id Binding data Representative ligand
1FWV kd = 0.19 mM SGA-MAG-FUC
1DQO   NGL
1FWU kd = 0.2 mM SGA-MAG-FUC
90% Homology Family
Leader: 1FHX
STRUCTURE OF THE PLECKSTRIN HOMOLOGY DOMAIN FROM
GRP1 IN COMPLEX WITH INOSITOL 1,3,4,5-TETRAKISPHOSPHATE
PDB id Binding data Representative ligand
1FHX kd = 0.027 uM 4IP
1FGY   4IP
1FHW kd = 0.33 uM I5P
90% Homology Family
Leader: 3FAT
X-RAY STRUCTURE OF IGLUR4 FLIP LIGAND-BINDING CORE (S1S2)
PDB id Binding data Representative ligand
3FAT Ki = 22.8 nM AMQ
3FAS Ki = 171.0 nM GLU
90% Homology Family
Leader: 3DP4
CRYSTAL STRUCTURE OF THE BINDING DOMAIN OF THE AMPA SUBUNIT
PDB id Binding data Representative ligand
3DP4 Kd = 43.0 nM AMQ
3DLN   GLU
90% Homology Family
Leader: 2ZSH
STRUCTURAL BASIS OF GIBBERELLIN(GA3)-INDUCED DELLA
PDB id Binding data Representative ligand
2ZSH   GA3
2ZSI   GA4
90% Homology Family
Leader: 2RCA
CRYSTAL STRUCTURE OF THE NR3B LIGAND BINDING CORE COMPLEX
PDB id Binding data Representative ligand
2RCA Kd = 16.4 nM GLY
2RCB   DSN
90% Homology Family
Leader: 1MH1
SMALL G-PROTEIN
PDB id Binding data Representative ligand
1MH1   GNP
2P2L   GDP
90% Homology Family
Leader: 2OM1
STRUCTURE OF HUMAN INSULIN IN PRESENCE OF THIOCYANATE AT PH
PDB id Binding data Representative ligand
2OM1   RCO
2OM0   RCO
90% Homology Family
Leader: 2HFN
CRYSTAL STRUCTURES OF THE SYNECHOCYSTIS PHOTORECEPTOR
SLR1694 REVEAL DISTINCT STRUCTURAL STATES
RELATED TO SIGNALING
PDB id Binding data Representative ligand
2HFN   FMN
2HFO   FMN
90% Homology Family
Leader: 2CE8
AN EH1 PEPTIDE BOUND TO THE GROUCHO-TLE WD40 DOMAIN.
PDB id Binding data Representative ligand
2CE8   MET-PHE-SER-ILE-ASP-ASN-ILE-LEU-ALA
2CE9   MET-TRP-ARG-PRO-TRP
90% Homology Family
Leader: 1ZC3
CRYSTAL STRUCTURE OF THE RAL-BINDING DOMAIN OF EXO84 IN
PDB id Binding data Representative ligand
1ZC3   GNP
1ZC4   GNP
90% Homology Family
Leader: 1X1R
CRYSTAL STRUCTURE OF M-RAS IN COMPLEX WITH GDP
PDB id Binding data Representative ligand
1X1R   GDP
1X1S   GNP
90% Homology Family
Leader: 1V3S
CRYSTAL STRUCTURE OF TT1020 FROM THERMUS THERMOPHILUS HB8
PDB id Binding data Representative ligand
1V3S   ATP
1V9O   ADP
90% Homology Family
Leader: 1US5
PUTATIVE GLUR0 LIGAND BINDING CORE WITH L-GLUTAMATE
PDB id Binding data Representative ligand
1US5   GLU
1US4   GLU
90% Homology Family
Leader: 1SE0
CRYSTAL STRUCTURE OF DIAP1 BIR1 BOUND TO A GRIM PEPTIDE
PDB id Binding data Representative ligand
1SE0   ALA-ILE-ALA-TYR-PHE-ILE-PRO-ASP-GLN-ALA
1SDZ   ALA-VAL-ALA-PHE-TYR-ILE-PRO-ASP-GLN-ALA
90% Homology Family
Leader: 1QSC
CRYSTAL STRUCTURE OF THE TRAF DOMAIN OF TRAF2
IN A COMPLEX WITH A PEPTIDE FROM THE CD40 RECEPTOR
PDB id Binding data Representative ligand
1QSC kd = 210.0 uM ACE-TYR-PRO-ILE-GLN-GLU-THR
1CA9   GLY-GLN-VAL-PRO-PHE-SER-LYS-GLU-GLU-CYS
90% Homology Family
Leader: 1OXN
STRUCTURE AND FUNCTION ANALYSIS OF PEPTIDE ANTAGONISTS OF
PDB id Binding data Representative ligand
1OXN Ki = 0.5 uM ALA-GLU-ALA-VAL-PRO-TRP-LYS-SER-GLU
1OXQ Ki = 2.1 uM ALA-VAL-PRO-ILE-ALA-GLN-LYS-SER-GLU
90% Homology Family
Leader: 1OBX
CRYSTAL STRUCTURE OF THE COMPLEX OF PDZ2 OF SYNTENIN
WITH AN INTERLEUKIN 5 RECEPTOR ALPHA PEPTIDE.
PDB id Binding data Representative ligand
1OBX kd = 1.9 uM GLU-THR-LEU-GLU-ASP-SER-VAL-PHE
1OBY kd = 2.3 uM THR-ASN-GLU-PHE-TYR-ALA
90% Homology Family
Leader: 3E7C
GLUCOCORTICOID RECEPTOR LBD BOUND TO GSK866
PDB id Binding data Representative ligand
3E7C   866
1NHZ   486
90% Homology Family
Leader: 1MFG
THE STRUCTURE OF ERBIN PDZ DOMAIN BOUND TO THE
CARBOXY-TERMINAL TAIL OF THE ERBB2 RECEPTOR
PDB id Binding data Representative ligand
1MFG kd ~ 50.0 uM GLU-TYR-LEU-GLY-LEU-ASP-VAL-PRO-VAL
1MFL kd ~ 128.0 uM GLU-PTR-LEU-GLY-LEU-ASP-VAL-PRO-VAL
90% Homology Family
Leader: 1LB6
TRAF6-CD40 COMPLEX
PDB id Binding data Representative ligand
1LB6 kd = 84.0 uM LYS-GLN-GLU-PRO-GLN-GLU-ILE-ASP-PHE
1LB5   GLN-MET-PRO-THR-GLU-ASP-GLU-TYR
90% Homology Family
Leader: 1KAO
CRYSTAL STRUCTURE OF THE SMALL G PROTEIN RAP2A WITH GDP
PDB id Binding data Representative ligand
1KAO   GDP
3RAP   GTP
90% Homology Family
Leader: 1G16
CRYSTAL STRUCTURE OF SEC4-GDP
PDB id Binding data Representative ligand
1G16   GDP
1G17   GTN
90% Homology Family
Leader: 1BFB
BASIC FIBROBLAST GROWTH FACTOR COMPLEXED WITH
HEPARIN TETRAMER FRAGMENT
PDB id Binding data Representative ligand
1BFB   UAP-SGN-IDU-SGN
1BFC   UAP-SGN-IDU-SGN-IDU-SGN
90% Homology Family
Leader: 3EA5
KAP95P BINDING INDUCES THE SWITCH LOOPS OF RANGDP TO ADOPT
PDB id Binding data Representative ligand
3EA5   GDP-MG
90% Homology Family
Leader: 3E70
STRUCTURES AND CONFORMATIONS IN SOLUTION OF THE SIGNAL
PDB id Binding data Representative ligand
3E70   GDP
90% Homology Family
Leader: 3E6J
CRYSTAL STRUCTURE OF VARIABLE LYMPHOCYTE RECEPTOR (VLR)
PDB id Binding data Representative ligand
3E6J   DR2
90% Homology Family
Leader: 3CWD
MOLECULAR RECOGNITION OF NITRO-FATTY ACIDS BY PPAR GAMMA
PDB id Binding data Representative ligand
3CWD   LNA
90% Homology Family
Leader: 3CH5
THE CRYSTAL STRUCTURE OF THE RANGDP-NUP153ZNF2 COMPLEX
PDB id Binding data Representative ligand
3CH5   GDP
90% Homology Family
Leader: 3C4M
STRUCTURE OF HUMAN PARATHYROID HORMONE IN COMPLEX WITH THE
PDB id Binding data Representative ligand
3C4M   MAL
90% Homology Family
Leader: 3B9Q
THE CRYSTAL STRUCTURE OF CPFTSY FROM ARABIDOPSIS THALIANA
PDB id Binding data Representative ligand
3B9Q   MLI
90% Homology Family
Leader: 2Z81
CRYSTAL STRUCTURE OF THE TLR1-TLR2 HETERODIMER INDUCED BY
PDB id Binding data Representative ligand
2Z81   PCJ
90% Homology Family
Leader: 2Z7X
CRYSTAL STRUCTURE OF THE TLR1-TLR2 HETERODIMER INDUCED BY
PDB id Binding data Representative ligand
2Z7X   SER-LYS-LYS-LYS-LYS-PCJ
90% Homology Family
Leader: 2V5E
THE STRUCTURE OF THE GDNF\:CORECEPTOR COMPLEX\: INSIGHTS
PDB id Binding data Representative ligand
2V5E   SCR
90% Homology Family
Leader: 2V3U
STRUCTURE OF THE LIGAND-BINDING CORE OF THE IONOTROPIC
PDB id Binding data Representative ligand
2V3U Kd = 1.0 mM DSN
90% Homology Family
Leader: 2R40
CRYSTAL STRUCTURE OF 20E BOUND ECR/USP
PDB id Binding data Representative ligand
2R40   20E
90% Homology Family
Leader: 2QT5
CRYSTAL STRUCTURE OF GRIP1 PDZ12 IN COMPLEX WITH THE FRAS1
PDB id Binding data Representative ligand
2QT5 Kd ~ 9.4 uM ASN-ASN-LEU-GLN-ASP-GLY-THR-GLU-VAL
90% Homology Family
Leader: 2PYY
CRYSTAL STRUCTURE OF THE GLUR0 LIGAND-BINDING CORE FROM
PDB id Binding data Representative ligand
2PYY Kd = 0.2 uM GLU
90% Homology Family
Leader: 2PR5
STRUCTURAL BASIS FOR LIGHT-DEPENDENT SIGNALING IN THE
PDB id Binding data Representative ligand
2PR5   FMN
90% Homology Family
Leader: 2PJL
CRYSTAL STRUCTURE OF HUMAN ESTROGEN-RELATED RECEPTOR ALPHA
PDB id Binding data Representative ligand
2PJL ic50 = 190.0 nM 047
90% Homology Family
Leader: 2OVH
PROGESTERONE RECEPTOR WITH BOUND ASOPRISNIL AND A PEPTIDE
PDB id Binding data Representative ligand
2OVH ic50 = 1.0 nM AS0
90% Homology Family
Leader: 2OG2
CRYSTAL STRUCTURE OF CHLOROPLAST FTSY FROM ARABIDOPSIS
PDB id Binding data Representative ligand
2OG2   MLI
90% Homology Family
Leader: 2NPA
THE CRYSTAL STRUCTURE OF THE HUMAN PPARAPLPHA LIGAND
PDB id Binding data Representative ligand
2NPA   MMB
90% Homology Family
Leader: 2LIG
THREE-DIMENSIONAL STRUCTURES OF THE LIGAND-BINDING
DOMAIN OF THE BACTERIAL ASPARTATE RECEPTOR WITH
AND WITHOUT A LIGAND
PDB id Binding data Representative ligand
2LIG   ASP
90% Homology Family
Leader: 2JF9
ESTROGEN RECEPTOR ALPHA LBD IN COMPLEX WITH A TAMOXIFEN-
PDB id Binding data Representative ligand
2JF9   OHT
90% Homology Family
Leader: 2HC4
CRYSTAL STRUCTURE OF THE LBD OF VDR OF DANIO RERIO IN
PDB id Binding data Representative ligand
2HC4   VDX
90% Homology Family
Leader: 2GNK
GLNK, A SIGNAL PROTEIN FROM E. COLI
PDB id Binding data Representative ligand
2GNK   ATP
90% Homology Family
Leader: 2FH5
THE STRUCTURE OF THE MAMMALIAN SRP RECEPTOR
PDB id Binding data Representative ligand
2FH5   GTP
90% Homology Family
Leader: 2D0N
CRYSTAL STRUCTURE OF THE GADS-CSH3 DOMAIN IN COMPLEX WITH
PDB id Binding data Representative ligand
2D0N   PRO-SER-ILE-ASP-ARG-SER-THR-LYS-PRO
90% Homology Family
Leader: 2AO6
CRYSTAL STRUCTURE OF THE HUMAN ANDROGEN RECEPTOR
LIGAND BINDING DOMAIN BOUND WITH TIF2(III
) 740-753 PEPTIDE AND R1881
PDB id Binding data Representative ligand
2AO6   R18
90% Homology Family
Leader: 2AK5
BETA PIX-SH3 COMPLEXED WITH A CBL-B PEPTIDE
PDB id Binding data Representative ligand
2AK5 Kd = 14.0 uM ARG-PRO-PRO-LYS-PRO-ARG-PRO-ARG
90% Homology Family
Leader: 2A5T
CRYSTAL STRUCTURE OF THE NR1/NR2A LIGAND-BINDING
CORES COMPLEX
PDB id Binding data Representative ligand
2A5T   GLY
90% Homology Family
Leader: 2A5S
CRYSTAL STRUCTURE OF THE NR2A LIGAND BINDING
CORE IN COMPLEX WITH GLUTAMATE
PDB id Binding data Representative ligand
2A5S   GLU
90% Homology Family
Leader: 1ZEI
CROSS-LINKED B28 ASP INSULIN
PDB id Binding data Representative ligand
1ZEI   CRS
90% Homology Family
Leader: 1YUK
THE CRYSTAL STRUCTURE OF THE PSI/HYBRID DOMAIN/ I-EGF1
PDB id Binding data Representative ligand
1YUK   NAG
90% Homology Family
Leader: 1YTV
MALTOSE-BINDING PROTEIN FUSION TO A C-TERMINAL FRAGMENT OF
PDB id Binding data Representative ligand
1YTV   MAL
90% Homology Family
Leader: 1Y3A
STRUCTURE OF G-ALPHA-I1 BOUND TO A GDP-SELECTIVE PEPTIDE
PDB id Binding data Representative ligand
1Y3A   GDP
90% Homology Family
Leader: 1XTQ
STRUCTURE OF SMALL GTPASE HUMAN RHEB IN COMPLEX WITH GDP
PDB id Binding data Representative ligand
1XTQ   GDP
90% Homology Family
Leader: 1XKW
PYOCHELIN OUTER MEMBRANE RECEPTOR FPTA FROM PSEUDOMONAS
AERUGINOSA
PDB id Binding data Representative ligand
1XKW   188
90% Homology Family
Leader: 1VLT
LIGAND BINDING DOMAIN OF THE WILD-TYPE ASPARTATE
RECEPTOR WITH ASPARTATE
PDB id Binding data Representative ligand
1VLT   ASP
90% Homology Family
Leader: 1UPR
CRYSTAL STRUCTURE OF THE PEPP1 PLECKSTRIN HOMOLOGY DOMAIN
PDB id Binding data Representative ligand
1UPR   ITS
90% Homology Family
Leader: 1U3D
CRYSTAL STRUCTURE OF THE PHR DOMAIN OF CRYPTOCHROME 1 FROM
PDB id Binding data Representative ligand
1U3D Kd = 75.0 uM ANP
90% Homology Family
Leader: 1U18
1.96 A CRYSTAL STRUCTURE OF H60C MUTANT OF NITROPHORIN
PDB id Binding data Representative ligand
1U18   HSM
90% Homology Family
Leader: 1TJY
CRYSTAL STRUCTURE OF SALMONELLA TYPHIMURIUM AI-2 RECEPTOR
PDB id Binding data Representative ligand
1TJY   PAV
90% Homology Family
Leader: 1T7R
CRYSTAL STRUCTURE OF THE ANDROGEN RECEPTOR LIGAND BINDING
PDB id Binding data Representative ligand
1T7R   DHT
90% Homology Family
Leader: 1T7M
CRYSTAL STRUCTURE OF THE ANDROGEN RECEPTOR LIGAND BINDING
PDB id Binding data Representative ligand
1T7M   DHT
90% Homology Family
Leader: 1T7F
CRYSTAL STRUCTURE OF THE ANDROGEN RECEPTOR LIGAND BINDING
PDB id Binding data Representative ligand
1T7F   DHT
90% Homology Family
Leader: 1T79
CRYSTAL STRUCTURE OF THE ANDROGEN RECEPTOR LIGAND BINDING
PDB id Binding data Representative ligand
1T79   DHT
90% Homology Family
Leader: 1T76
CRYSTAL STRUCTURE OF THE ANDROGEN RECEPTOR LIGAND BINDING
PDB id Binding data Representative ligand
1T76   DHT
90% Homology Family
Leader: 1T74
CRYSTAL STRUCTURE OF THE ANDROGEN RECEPTOR LIGAND BINDING
PDB id Binding data Representative ligand
1T74   DHT
90% Homology Family
Leader: 1T73
CRYSTAL STRUCTURE OF THE ANDROGEN RECEPTOR LIGAND BINDING
PDB id Binding data Representative ligand
1T73   DHT
90% Homology Family
Leader: 1T65
CRYSTAL STRUCTURE OF THE ANDROGEN RECEPTOR LIGAND BINDING
PDB id Binding data Representative ligand
1T65   DHT
90% Homology Family
Leader: 1T5Z
CRYSTAL STRUCTURE OF THE ANDROGEN RECEPTOR LIGAND BINDING
PDB id Binding data Representative ligand
1T5Z   DHT
90% Homology Family
Leader: 1T15
CRYSTAL STRUCTURE OF THE BRCA1 BRCT DOMAINS IN COMPLEX WITH
PDB id Binding data Representative ligand
1T15   SER-THR-SEP-PRO-THR-PHE-ASN-LYS
90% Homology Family
Leader: 1RZX
CRYSTAL STRUCTURE OF A PAR-6 PDZ-PEPTIDE COMPLEX
PDB id Binding data Representative ligand
1RZX Kd = 80.0 uM ACE-VAL-LYS-GLU-SER-LEU-VAL
90% Homology Family
Leader: 1RPJ
CRYSTAL STRUCTURE OF D-ALLOSE BINDING PROTEIN
FROM ESCHERICHIA COLI
PDB id Binding data Representative ligand
1RPJ kd = 0.33 uM ALL
90% Homology Family
Leader: 1RDT
CRYSTAL STRUCTURE OF A NEW REXINOID BOUND TO THE RXRALPHA
PDB id Binding data Representative ligand
1RDT Ki = 6.0 nM L79
90% Homology Family
Leader: 1PWB
HIGH RESOLUTION CRYSTAL STRUCTURE OF AN ACTIVE
RECOMBINANT FRAGMENT OF HUMAN LUNG SURFACTANT
PROTEIN D WITH MALTOSE
PDB id Binding data Representative ligand
1PWB   GLC
90% Homology Family
Leader: 1PUJ
STRUCTURE OF B. SUBTILIS YLQF GTPASE
PDB id Binding data Representative ligand
1PUJ   GNP
90% Homology Family
Leader: 1OFU
CRYSTAL STRUCTURE OF SULA:FTSZ FROM PSEUDOMONAS AERUGINOSA
PDB id Binding data Representative ligand
1OFU   GDP
90% Homology Family
Leader: 1N7F
CRYSTAL STRUCTURE OF THE SIXTH PDZ DOMAIN OF
GRIP1 IN COMPLEX WITH LIPRIN C-TERMINAL PEPTIDE
PDB id Binding data Representative ligand
1N7F   ALA-THR-VAL-ARG-THR-TYR-SER-CYS
90% Homology Family
Leader: 1N4K
CRYSTAL STRUCTURE OF THE INOSITOL 1,4,5-TRISPHOSPHATE
RECEPTOR BINDING CORE IN COMPLEX WITH IP3
PDB id Binding data Representative ligand
1N4K kd = 0.09 nM I3P
90% Homology Family
Leader: 1N1I
THE STRUCTURE OF MSP-1(19) FROM PLASMODIUM KNOWLESI
PDB id Binding data Representative ligand
1N1I   HIS
90% Homology Family
Leader: 1MR3
SACCHAROMYCES CEREVISIAE ADP-RIBOSYLATION FACTOR
2 (SCARF2) COMPLEXED WITH GDP-3'P AT 1.6A RESOLUTION
PDB id Binding data Representative ligand
1MR3   G3D
90% Homology Family
Leader: 1M7E
CRYSTAL STRUCTURE OF THE PHOSPHOTYROSINE BINDING
DOMAIN(PTB) OF MOUSE DISABLED 2(DAB2):IMPLICATIONS
FOR REELING SIGNALING
PDB id Binding data Representative ligand
1M7E   ASN-GLY-TYR-GLU-ASN-PRO-THR-TYR-LYS
90% Homology Family
Leader: 1M7B
CRYSTAL STRUCTURE OF RND3/RHOE: FUNCTIONAL IMPLICATIONS
PDB id Binding data Representative ligand
1M7B   GTP
90% Homology Family
Leader: 1M2Z
CRYSTAL STRUCTURE OF A DIMER COMPLEX OF THE HUMAN
GLUCOCORTICOID RECEPTOR LIGAND-BINDING DOMAIN
BOUND TO DEXAMETHASONE AND A TIF2 COACTIVATOR MOTIF
PDB id Binding data Representative ligand
1M2Z   BOG
90% Homology Family
Leader: 1LV0
CRYSTAL STRUCTURE OF THE RAB EFFECTOR GUANINE
NUCLEOTIDE DISSOCIATION INHIBITOR (GDI) IN COMPLEX
WITH A GERANYLGERANYL (GG) PEPTIDE
PDB id Binding data Representative ligand
1LV0   GER
90% Homology Family
Leader: 1LR8
CRYSTAL STRUCTURE OF FS1, THE HEPARIN-BINDING
DOMAIN OF FOLLISTATIN, COMPLEXED WITH THE HEPARIN
ANALOGUE D-MYO-INOSITOL HEXASULPHATE (INS6S)
PDB id Binding data Representative ligand
1LR8 kd = 10.0 nM IHS
90% Homology Family
Leader: 1JX6
CRYSTAL STRUCTURE OF LUXP FROM VIBRIO HARVEYI
COMPLEXED WITH AUTOINDUCER-2
PDB id Binding data Representative ligand
1JX6   AI2
90% Homology Family
Leader: 1JD5
CRYSTAL STRUCTURE OF DIAP1-BIR2/GRIM
PDB id Binding data Representative ligand
1JD5 kd = 0.24 uM ALA-ILE-ALA-TYR-PHE-ILE-PRO-ASP-GLN-ALA
90% Homology Family
Leader: 1J6X
CRYSTAL STRUCTURE OF HELICOBACTER PYLORI LUXS
PDB id Binding data Representative ligand
1J6X   MET
90% Homology Family
Leader: 1J6W
CRYSTAL STRUCTURE OF HAEMOPHILUS INFLUENZAE LUXS
PDB id Binding data Representative ligand
1J6W   MET
90% Homology Family
Leader: 1ION
THE SEPTUM SITE-DETERMINING PROTEIN MIND COMPLEXED
WITH MG-ADP FROM PYROCOCCUS HORIKOSHII OT3
PDB id Binding data Representative ligand
1ION   ADP
90% Homology Family
Leader: 1I7E
C-TERMINAL DOMAIN OF MOUSE BRAIN TUBBY PROTEIN
BOUND TO PHOSPHATIDYLINOSITOL 4,5-BIS-PHOSPHATE
PDB id Binding data Representative ligand
1I7E   IBS
90% Homology Family
Leader: 1I7A
EVH1 DOMAIN FROM MURINE HOMER 2B/VESL 2
PDB id Binding data Representative ligand
1I7A   FLC
90% Homology Family
Leader: 1I4D
CRYSTAL STRUCTURE ANALYSIS OF RAC1-GDP COMPLEXED
WITH ARFAPTIN (P21)
PDB id Binding data Representative ligand
1I4D kd = 3.0 uM GDP
90% Homology Family
Leader: 1HE1
CRYSTAL STRUCTURE OF THE COMPLEX BETWEEN THE
GAP DOMAIN OF THE PSEUDOMONAS AERUGINOSA EXOS
TOXIN AND HUMAN RAC
PDB id Binding data Representative ligand
1HE1   AF3
90% Homology Family
Leader: 1H9O
PHOSPHATIDYLINOSITOL 3-KINASE, P85-ALPHA SUBUNIT:
C-TERMINAL SH2 DOMAIN COMPLEXED WITH A TYR751
PHOSPHOPEPTIDE FROM THE PDGF RECEPTOR, CRYSTAL
STRUCTURE AT 1.79 A
PDB id Binding data Representative ligand
1H9O   PTR-VAL-PRO-MET-LEU
90% Homology Family
Leader: 1GWN
THE CRYSTAL STRUCTURE OF THE CORE DOMAIN OF RHOE/RND3
- A CONSTITUTIVELY ACTIVATED SMALL G PROTEIN
PDB id Binding data Representative ligand
1GWN   GTP
90% Homology Family
Leader: 1GMN
CRYSTAL STRUCTURES OF NK1-HEPARIN COMPLEXES REVEAL
THE BASIS FOR NK1 ACTIVITY AND ENABLE ENGINEERING
OF POTENT AGONISTS OF THE MET RECEPTOR
PDB id Binding data Representative ligand
1GMN   IDS-SGN-IDS-SGN-IDS
90% Homology Family
Leader: 1G4U
CRYSTAL STRUCTURE OF THE SALMONELLA TYROSINE
PHOSPHATASE AND GTPASE ACTIVATING PROTEIN SPTP BOUND TO RAC1
PDB id Binding data Representative ligand
1G4U   GDP
90% Homology Family
Leader: 1G3Q
CRYSTAL STRUCTURE ANALYSIS OF PYROCOCCUS FURIOSUS
CELL DIVISION ATPASE MIND
PDB id Binding data Representative ligand
1G3Q   ADP
90% Homology Family
Leader: 1FZQ
CRYSTAL STRUCTURE OF MURINE ARL3-GDP
PDB id Binding data Representative ligand
1FZQ kd = 24.0 nM GDP
90% Homology Family
Leader: 1FNN
CRYSTAL STRUCTURE OF CDC6P FROM PYROBACULUM AEROPHILUM
PDB id Binding data Representative ligand
1FNN   ADP
90% Homology Family
Leader: 1FCH
CRYSTAL STRUCTURE OF THE PTS1 COMPLEXED TO THE
TPR REGION OF HUMAN PEX5
PDB id Binding data Representative ligand
1FCH kd = 70.0 nM TYR-GLN-SER-LYS-LEU
90% Homology Family
Leader: 1FAO
STRUCTURE OF THE PLECKSTRIN HOMOLOGY DOMAIN FROM
DAPP1/PHISH IN COMPLEX WITH INOSITOL 1,3,4,5
-TETRAKISPHOSPHATE
PDB id Binding data Representative ligand
1FAO kd = 0.043 uM ITS
90% Homology Family
Leader: 1F5N
HUMAN GUANYLATE BINDING PROTEIN-1 IN COMPLEX
WITH THE GTP ANALOGUE, GMPPNP.
PDB id Binding data Representative ligand
1F5N   GNP
90% Homology Family
Leader: 1EWK
CRYSTAL STRUCTURE OF METABOTROPIC GLUTAMATE RECEPTOR
SUBTYPE 1 COMPLEXED WITH GLUTAMATE
PDB id Binding data Representative ligand
1EWK   GLU
90% Homology Family
Leader: 1E96
STRUCTURE OF THE RAC/P67PHOX COMPLEX
PDB id Binding data Representative ligand
1E96 kd = 2.7 uM GTP
90% Homology Family
Leader: 1DS6
CRYSTAL STRUCTURE OF A RAC-RHOGDI COMPLEX
PDB id Binding data Representative ligand
1DS6   GDP
90% Homology Family
Leader: 1DDV
CRYSTAL STRUCTURE OF THE HOMER EVH1 DOMAIN WITH
BOUND MGLUR PEPTIDE
PDB id Binding data Representative ligand
1DDV   THR-PRO-PRO-SER-PRO-PHE
90% Homology Family
Leader: 1CX4
CRYSTAL STRUCTURE OF A DELETION MUTANT OF THE
TYPE II BETA REGULATORY SUBUNIT OF CAMP-DEPENDENT
PROTEIN KINASE
PDB id Binding data Representative ligand
1CX4   CMP
90% Homology Family
Leader: 1CM0
CRYSTAL STRUCTURE OF THE PCAF/COENZYME-A COMPLEX
PDB id Binding data Representative ligand
1CM0   COA
90% Homology Family
Leader: 1BTN
STRUCTURE OF THE BINDING SITE FOR INOSITOL PHOSPHATES
IN A PH DOMAIN
PDB id Binding data Representative ligand
1BTN kd = 40.0 uM I3P
90% Homology Family
Leader: 1BH2
A326S MUTANT OF AN INHIBITORY ALPHA SUBUNIT
PDB id Binding data Representative ligand
1BH2   GSP