Protein Class Information

IMMUNE

Families belonging to this class:

90% Homology Family

Leader:	3BHB	CRYSTAL STRUCTURE OF KMD PHOSPHOPEPTIDE BOUND TO HUMAN

PDB id	Binding data	Representative ligand
3BHB	ic50 = 3.4 nM	LYS-MET-ASP-SEP-PHE-LEU-ASP-MET-GLN-LEU
1B0G		ALA-LEU-TRP-GLY-PHE-PHE-PRO-VAL-LEU
1DUY		LEU-PHE-GLY-TYR-PRO-VAL-TYR-VAL
1DUZ		LEU-LEU-PHE-GLY-TYR-PRO-VAL-TYR-VAL
1EEY		ILE-LEU-SER-ALA-LEU-VAL-GLY-ILE-VAL
1EEZ		ILE-LEU-SER-ALA-LEU-VAL-GLY-ILE-LEU
1HHI		GLY-ILE-LEU-GLY-PHE-VAL-PHE-THR-LEU
1HHJ		ILE-LEU-LYS-GLU-PRO-VAL-HIS-GLY-VAL
1HHK		LEU-LEU-PHE-GLY-TYR-PRO-VAL-TYR-VAL
1HSB		ALA-VAL-ALA
1I1Y		TYR-LEU-LYS-GLU-PRO-VAL-HIS-GLY-VAL
1I4F		GLY-VAL-TYR-ASP-GLY-ARG-GLU-HIS-THR-VAL
1I7R		PHE-ALA-PRO-GLY-PHE-PHE-PRO-TYR-LEU
1I7U		ALA-LEU-TRP-GLY-PHE-VAL-PRO-VAL-LEU
1JF1		GLU-LEU-ALA-GLY-ILE-GLY-ILE-LEU-THR-VAL
1JHT		ALA-LEU-GLY-ILE-GLY-ILE-LEU-THR-VAL
1Q94		ALA-ILE-PHE-GLN-SER-SER-MET-THR-LYS
1QEW		PHE-LEU-TRP-GLY-PRO-ARG-ALA-LEU-VAL
1QR1		ILE-ILE-SER-ALA-VAL-VAL-GLY-ILE-LEU
1QVO		GLN-VAL-PRO-LEU-ARG-PRO-MET-THR-TYR-LYS
1S8D		SER-LEU-ALA-ASN-THR-VAL-ALA-THR-LEU
1S9W		SER-LEU-LEU-MET-TRP-ILE-THR-GLN-CYS
1S9X		SER-LEU-LEU-MET-TRP-ILE-THR-GLN-ALA
1S9Y		SER-LEU-LEU-MET-TRP-ILE-THR-GLN-SER
1T1W		SER-LEU-PHE-ASN-THR-ILE-ALA-VAL-LEU
1T1X		SER-LEU-TYR-LEU-THR-VAL-ALA-THR-LEU
1T1Y		SER-LEU-TYR-ASN-VAL-VAL-ALA-THR-LEU
1T1Z		ALA-LEU-TYR-ASN-THR-ALA-ALA-ALA-LEU
1T20		SER-LEU-TYR-ASN-THR-ILE-ALA-THR-LEU
1T21		SER-LEU-TYR-ASN-THR-VAL-ALA-THR-LEU
1T22		SER-LEU-TYR-ASN-THR-VAL-ALA-THR-LEU
1TVB		ILE-THR-ASP-GLN-VAL-PRO-PHE-SER-VAL
1TVH		ILE-MET-ASP-GLN-VAL-PRO-PHE-SER-VAL
1X7Q		LYS-THR-PHE-PRO-PRO-THR-GLU-PRO-LYS
2AV1		LEU-LEU-PHE-GLY-TYR-PRO-VAL-TYR-VAL
2AV7		LEU-LEU-PHE-GLY-TYR-PRO-VAL-TYR-VAL
2C7U	Kd = 100.0 nM	SER-LEU-PHE-ASN-THR-ILE-ALA-VAL-LEU
2CLR		MET-LEU-LEU-SER-VAL-PRO-LEU-LEU-LEU-GLY
2GIT		LEU-LEU-PHE-GLY-LYS-PRO-VAL-TYR-VAL
2GT9		GLU-ALA-ALA-GLY-ILE-GLY-ILE-LEU-THR-VAL
2GTW		LEU-ALA-GLY-ILE-GLY-ILE-LEU-THR-VAL
2GTZ		ALA-LEU-GLY-ILE-GLY-ILE-LEU-THR-VAL
2GUO		ALA-ALA-GLY-ILE-GLY-ILE-LEU-THR-VAL
2HN7	ic50 = 31.0 nM	ALA-ILE-MET-PRO-ALA-ARG-PHE-TYR-PRO-LYS
2V2W	Kd = 2.2 uM	SER-LEU-TYR-ASN-THR-VAL-ALA-THR-LEU
2V2X	Kd = 5.2 uM	SER-LEU-PHE-ASN-THR-VAL-ALA-THR-LEU
2VLL		GLY-ILE-LEU-GLY-PHE-VAL-PHE-THR-LEU
3BGM	ic50 = 32.5 nM	ARG-GLN-ALA-SEP-LEU-SER-ILE-SER-VAL
3BH8	ic50 = 11.2 nM	ARG-GLN-ALA-SEP-ILE-GLU-LEU-PRO-SER-MET
3BH9	ic50 = 116.9 nM	ARG-THR-TYR-SEP-GLY-PRO-MET-ASN-LYS-VAL
3BO8		GLU-ALA-ASP-PRO-THR-GLY-HIS-SER-TYR

90% Homology Family

Leader:	2R1X	CRYSTAL STRUCTURE OF S25-2 FAB IN COMPLEX WITH KDO ANALOGUES

PDB id	Binding data	Representative ligand
2R1X	Kd = 16.0 uM	KDD-KDA
1Q9Q		KDA-KDO-KDO
1Q9R		KDA-KDO
1Q9T		KDA-KDO
1Q9V		KDO
1Q9W		KDO-KDO-KDO
2G5B		PRO-THR-SER-SER-GLU-GLN-ILE
2R1W	Kd = 25.0 uM	KDB-KDA
2R1Y	Kd = 31.0 uM	KDR-KDO
2R23	Kd = 190.0 uM	KO1-KDA
2R2B		KDA-KDO-KDO
2R2E		KDE
2R2H		KO2

90% Homology Family

Leader:	1TJG	CRYSTAL STRUCTURE OF THE BROADLY NEUTRALIZING ANTI-HIV-1

PDB id	Binding data	Representative ligand
1TJG		GLU-LEU-ASP-LYS-TRP-ALA-SER
1U8H		ALA-LEU-ASP-LYS-TRP-ALA-SER
1U8I		GLU-LEU-ASP-LYS-TRP-ALA-ASN
1U8J		GLU-LEU-ASP-LYS-TRP-ALA-GLY
1U8K		LEU-GLU-LEU-ASP-LYS-TRP-ALA-SER-LEU
1U8M		GLU-LEU-ASP-LYS-TYR-ALA-SER
1U8Q		GLU-LEU-GLU-LYS-TRP-ALA-SER
1U91		GLU-ASN-ASP-LYS-TRP-ALA-SER
1U92		GLU-ALA-ASP-LYS-TRP-GLN-SER
1U93		GLU-GLN-ASP-LYS-TRP-ALA-SER
1U95		GLU-LEU-ASP-HIS-TRP-ALA-SER
2F5B		GLU-LEU-ASP-LYS-TRP-ALA-SER

90% Homology Family

Leader:	3E2M	LFA-1 I DOMAIN BOUND TO INHIBITORS

PDB id	Binding data	Representative ligand
3E2M	ic50 = 0.4 nM	E2M
1RD4	Kd = 18.3 nM	L08
1XDD	IC50 = 0.2 uM	AAY
1XDG	IC50 = 0.05 uM	AB8
1XUO	IC50 = 69.0 nM	LA1
2ICA	IC50 = 20.0 nM	2IC
2O7N	ic50 = 15.0 nM	2O7
3BQM	Ki = 2.0 nM	BQM
3BQN	ic50 = 2.5 nM	BQN

90% Homology Family

Leader:	1YEJ	CATALYTIC ANTIBODY COMPLEX

PDB id	Binding data	Representative ligand
1YEJ	kd = 35.0 nM	PNF
1KN2		PNE
1KN4		PDE
1YEC		PNB
1YEE		PNB
1YEF		PNC
1YEG		BPN
1YEI	kd = 35.0 nM	PGG
1YEK		NPO

90% Homology Family

Leader:	1NCW	CATIONIC CYCLIZATION ANTIBODY 4C6 IN COMPLEX WITH BENZOIC ACID

PDB id	Binding data	Representative ligand
1NCW		BEZ
1ND0		DP4
1RU9		BEZ
1RUA		BEZ
1RUK		BEZ
1RUL		BEZ
1RUM		BEZ
1RUP		BEZ

90% Homology Family

Leader:	2BNQ	STRUCTURAL AND KINETIC BASIS FOR HEIGHTENED IMMUNOGENICITY

PDB id	Binding data	Representative ligand
2BNQ	kd = 5.0 uM	SER-LEU-LEU-MET-TRP-ILE-THR-GLN-VAL
2BNR	kd = 13.3 uM	SER-LEU-LEU-MET-TRP-ILE-THR-GLN-CYS
2F53		SER-LEU-LEU-MET-TRP-ILE-THR-GLN-CYS
2P5E		SER-LEU-LEU-MET-TRP-ILE-THR-GLN-CYS
2P5W		SER-LEU-LEU-MET-TRP-ILE-THR-GLN-CYS
2PYE		SER-LEU-LEU-MET-TRP-ILE-THR-GLN-CYS

90% Homology Family

Leader:	3DUR	CRYSTAL STRUCTURE OF SAG173-04

PDB id	Binding data	Representative ligand
3DUR		KDO
3DUS		KDO
3DUU		KDO
3DV4		KDO
3DV6		KDO

90% Homology Family

Leader:	1OAU	FV STRUCTURE OF THE IGE SPE-7 IN COMPLEX WITH DNP-SER

PDB id	Binding data	Representative ligand
1OAU	Kd = 20.0 nM	SER-DNF
1A6V		NPC
1A6W		NIP
1OAR	Kd = 40.0 nM	AZN
2BJM	Ka < 100000.0 M^-1	ANF

90% Homology Family

Leader:	2AJV	CRYSTAL STRUCTURE OF COCAINE CATALYTIC ANTIBODY 7A1 FAB' IN COMPLEX WITH COCAINE

PDB id	Binding data	Representative ligand
2AJV		COC
2AJX		TGN
2AJY		ECG
2AJZ		ECG
2AK1		BEZ

90% Homology Family

Leader:	1OGA	A STRUCTURAL BASIS FOR IMMUNODOMINANT HUMAN T -CELL RECEPTOR RECOGNITION.

PDB id	Binding data	Representative ligand
1OGA		GLY-ILE-LEU-GLY-PHE-VAL-PHE-THR-LEU
2VLJ		GLY-ILE-LEU-GLY-PHE-VAL-PHE-THR-LEU
2VLK		GLY-ILE-LEU-GLY-PHE-VAL-PHE-THR-LEU
2VLR		GLY-ILE-LEU-GLY-PHE-VAL-PHE-THR-LEU

90% Homology Family

Leader:	2FIK	STRUCTURE OF A MICROBIAL GLYCOSPHINGOLIPID BOUND TO MOUSE CD1D

PDB id	Binding data	Representative ligand
2FIK		GSL
1Z5L		PBS
2AKR		CIS
2Q7Y		IGC

90% Homology Family

Leader:	2BVE	STRUCTURE OF THE N-TERMINAL OF SIALOADHESIN IN COMPLEX WITH

PDB id	Binding data	Representative ligand
2BVE	ic50 = 215.0 uM	PH5
1OD9		BND
1QFO		SIA
1URL		ALA-GLY-HIS-THR-TRP-GLY-HIA-SIA

90% Homology Family

Leader:	1Q72	ANTI-COCAINE ANTIBODY M82G2 COMPLEXED WITH COCAINE

PDB id	Binding data	Representative ligand
1Q72	Kd = 1.4E-7 M	COC
1QYG		BCG
1RIU		RBE
1RIV		OBE

90% Homology Family

Leader:	1MFD	THE SOLUTION STRUCTURE OF A TRISACCHARIDE-ANTIBODY COMPLEX: COMPARISON OF NMR MEASUREMENTS WITH A CRYSTAL STRUCTURE

PDB id	Binding data	Representative ligand
1MFD	kd = 4.9 uM	GAL-MMA-ABE
1MFB		GAL-MAN-ABE-RAM-MAN-RAM-GAL
1MFC		GAL-MAN-ABE-RAM
1MFE		GAL-MAN-ABE

90% Homology Family

Leader:	1D5Z	X-RAY CRYSTAL STRUCTURE OF HLA-DR4 COMPLEXED WITH PEPTIDOMIMETIC AND SEB

PDB id	Binding data	Representative ligand
1D5Z		ACE-HAC-ARG-ALA-ODA-SER-CLE
1D5M		ACE-HAC-ARG-ALA-MET-CY1-SER-CLE
1D5X		ACE-HAC-ARG-MAA-HAQ-SEL
1D6E		ACE-HAC-ARG-MPQ-MET-ALA-SER-BUG

90% Homology Family

Leader:	2R0Z	PFA1 FAB COMPLEXED WITH GRIPI PEPTIDE FRAGMENT

PDB id	Binding data	Representative ligand
2R0Z	Kd = 3400.0 nM	ALA-LYS-PHE-ARG-HIS-ASP
2IPU		ASP-ALA-GLU-PHE-ARG-HIS-ASP-SER
2R0W		ASP-ALA-GLU-PHE-ARG-HIS-ASP-SER

90% Homology Family

Leader:	1OP3	CRYSTAL STRUCTURE OF FAB 2G12 BOUND TO MAN1->2MAN

PDB id	Binding data	Representative ligand
1OP3		MAN
1ZLS		MAN-MAN-MAN-MAN
1ZLV		MAN-MAN-MAN-MAN

90% Homology Family

Leader:	2BMK	FAB FRAGMENT OF PLP-DEPENDENT CATALYTIC ANTIBODY 15A9 IN COMPLEX WITH PHOSPHOPYRIDOXYL-D-ALANINE

PDB id	Binding data	Representative ligand
2BMK	Kd = 1.5 uM	PDD
1WC7		PP3
1WCB	Kd = 26.0 nM	PE1

90% Homology Family

Leader:	1FL3	CRYSTAL STRUCTURE OF THE BLUE FLUORESCENT ANTIBODY (19G2) IN COMPLEX WITH STILBENE HAPTEN AT 277K

PDB id	Binding data	Representative ligand
1FL3	kd = 0.16 uM	SPB
1UB5		SPB
3CFB		SPB

90% Homology Family

Leader:	1M7D	CRYSTAL STRUCTURE OF A MONOCLONAL FAB SPECIFIC FOR SHIGELLA FLEXNERI Y LIPOPOLYSACCHARIDE COMPLEXED WITH A TRISACCHARIDE

PDB id	Binding data	Representative ligand
1M7D	Ka = 1700000.0 M^-1	RAA-RAE-1NA
1M7I	Ka = 250000.0 M^-1	RAA-RAA-RAA-NAG-RAO
1PZ5	Kd = 4.0 uM	MET-ASP-TRP-ASN-MET-HIS-ALA-ALA

90% Homology Family

Leader:	1MRE	PREPARATION, CHARACTERIZATION AND CRYSTALLIZATION OF AN ANTIBODY FAB FRAGMENT THAT RECOGNIZES RNA. CRYSTAL STRUCTURES OF NATIVE FAB AND THREE FAB -MONONUCLEOTIDE COMPLEXES

PDB id	Binding data	Representative ligand
1MRE		GDP
1MRD		IDP
1MRF		OIP

90% Homology Family

Leader:	1MH5	THE STRUCTURE OF THE COMPLEX OF THE FAB FRAGMENT OF THE

PDB id	Binding data	Representative ligand
1MH5	kd = 0.61 nM	HAL
1MJ7	kd = 4.5 nM	HAL
1MJJ	kd = 1.83 nM	HAL

90% Homology Family

Leader:	1LP9	XENOREACTIVE COMPLEX AHIII 12.2 TCR BOUND TO P1049/HLA-A2.1

PDB id	Binding data	Representative ligand
1LP9		ALA-LEU-TRP-GLY-PHE-PHE-PRO-VAL-LEU
2JCC		ALA-LEU-TRP-GLY-PHE-PHE-PRO-VAL-LEU
2UWE		ALA-LEU-TRP-GLY-PHE-PHE-PRO-VAL-LEU

90% Homology Family

Leader:	1LO2	RETRO-DIELS-ALDERASE CATALYTIC ANTIBODY

PDB id	Binding data	Representative ligand
1LO2		OX1
1LO0		BC1
1LO3		AN1

90% Homology Family

Leader:	1CFV	MONOCLONAL ANTIBODY FRAGMENT FV4155 FROM E. COLI

PDB id	Binding data	Representative ligand
1CFV	Ka ~ 1.0E8 M^-1	E3G
1BFV	Ka ~ 1.0E7 M^-1	STG
2BFV		STG

90% Homology Family

Leader:	3BZF	THE HUMAN NON-CLASSICAL MAJOR HISTOCOMPATIBILITY COMPLEX

PDB id	Binding data	Representative ligand
3BZF		VAL-MET-ALA-PRO-ARG-ALA-LEU-LEU-LEU
3BZE		VAL-MET-ALA-PRO-ARG-THR-LEU-PHE-LEU

90% Homology Family

Leader:	3BZ4	CRYSTAL STRUCTURE OF FAB F22-4 IN COMPLEX WITH A SHIGELLA

PDB id	Binding data	Representative ligand
3BZ4		EAG-RAM-RAM-GLC-RAM-NAG-RAM-RAM-GLC-RAM
3C6S		RAM-NAG-RAM-RAM-GLC-RAM-NAG-RAM-RAM-GLC-RAM

90% Homology Family

Leader:	3BIB	TIM-4 IN COMPLEX WITH PHOSPHATIDYLSERINE

PDB id	Binding data	Representative ligand
3BIB	ic50 = 4.0 mM	PSF
3BIA	ic50 = 125.0 mM	TLA

90% Homology Family

Leader:	35C8	CATALYTIC ANTIBODY 5C8, FAB-INHIBITOR COMPLEX

PDB id	Binding data	Representative ligand
35C8		NOX
25C8		GEP

90% Homology Family

Leader:	2Z93	CRYSTAL STRUCTURE OF FAB FRAGMENT OF ANTI-CIGUATOXIN

PDB id	Binding data	Representative ligand
2Z93	Kd = 11.1 nM	END
2Z92	Kd = 66.7 nM	ENE

90% Homology Family

Leader:	2JCQ	THE HYALURONAN BINDING DOMAIN OF MURINE CD44 IN A TYPE A

PDB id	Binding data	Representative ligand
2JCQ		NAG-GCU-NAG-GCU-NAG-GCU-5AX
2JCR		NAG-BDP-NAG-BDP-NAG-BDP-NAG

90% Homology Family

Leader:	2H26	HUMAN CD1B IN COMPLEX WITH ENDOGENOUS PHOSPHATIDYLCHOLINE AND SPACER

PDB id	Binding data	Representative ligand
2H26		6UL
1GZQ		PII

90% Homology Family

Leader:	2E56	CRYSTAL STRUCTURE OF HUMAN MD-2

PDB id	Binding data	Representative ligand
2E56		MYR
2E59		LP5-LP4

90% Homology Family

Leader:	2DQU	CRYSTAL FORM II: HIGH RESOLUTION CRYSTAL STRUCTURE OF THE COMPLEX OF THE HYDROLYTIC ANTIBODY FAB 6D9 AND A TRANSITION-STATE ANALOG

PDB id	Binding data	Representative ligand
2DQU	Ki = 50.0 nM	CPD
2DQT	Ki = 50.0 nM	CPD

90% Homology Family

Leader:	2CGR	LOCAL AND TRANSMITTED CONFORMATIONAL CHANGES ON COMPLEXATION OF AN ANTI-SWEETENER FAB

PDB id	Binding data	Representative ligand
2CGR	kd = 53.0 nM	GAS
1YNK		SC5

90% Homology Family

Leader:	2APH	CRYSTAL STRUCTURE OF HUMAN PGRP-IALPHAC IN COMPLEX WITH MURAMYL PENTAPEPTIDE

PDB id	Binding data	Representative ligand
2APH		AMU-ALA-GMA-LYS-DAL-DAL-NH2
1TWQ		AMU-ALA-GMA-LYS-NH2

90% Homology Family

Leader:	1Y8E	VCP:SURAMIN COMPLEX

PDB id	Binding data	Representative ligand
1Y8E		SVR
1RID		IDS-SGN-IDS-SGN-IDS-SGN-IDS-SGN

90% Homology Family

Leader:	1UM5	CATALYTIC ANTIBODY 21H3 WITH ALCOHOL SUBSTRATE

PDB id	Binding data	Representative ligand
1UM5		SS1
1UM4		SH4

90% Homology Family

Leader:	1SE4	STAPHYLOCOCCAL ENTEROTOXIN B COMPLEXED WITH LACTOSE

PDB id	Binding data	Representative ligand
1SE4		LAT
1SE3		SIA-GAL-GLC

90% Homology Family

Leader:	1NC2	CRYSTAL STRUCTURE OF MONOCLONAL ANTIBODY 2D12.5 FAB

PDB id	Binding data	Representative ligand
1NC2		DOE
1NC4		DOF

90% Homology Family

Leader:	1M48	CRYSTAL STRUCTURE OF HUMAN IL-2 COMPLEXED WITH (R)-N-[2-[1-(AMINOIMINOMETHYL)-3-PIPERIDINYL ]-1-OXOETHYL]-4-(PHENYLETHYNYL)-L-PHENYLALANINE METHYL ESTER

PDB id	Binding data	Representative ligand
1M48	kd = 8.2 uM	FRG
1M49		CMM

90% Homology Family

Leader:	1KEG	ANTIBODY 64M-2 FAB COMPLEXED WITH DTT(6-4)TT

PDB id	Binding data	Representative ligand
1KEG		T-64T-T-T
1EHL		5HT-T

90% Homology Family

Leader:	1GAF	48G7 HYBRIDOMA LINE FAB COMPLEXED WITH HAPTEN 5-(PARA-NITROPHENYL PHOSPHONATE)-PENTANOIC ACID

PDB id	Binding data	Representative ligand
1GAF	kd = 10.0 nM	NPE
1AJ7	kd = 135.0 uM	NPE

90% Homology Family

Leader:	1FNG	HISTOCOMPATIBILITY ANTIGEN

PDB id	Binding data	Representative ligand
1FNG		NAG
1FNE		NAG

90% Homology Family

Leader:	1E4X	CROSSREACTIVE BINDING OF A CIRCULARIZED PEPTIDE TO AN ANTI-TGFALPHA ANTIBODY FAB-FRAGMENT

PDB id	Binding data	Representative ligand
1E4X	kd = 25.0 nM	VAL-VAL-SER-HIS-PHE-ASN-ASP
1E4W	kd = 25.0 nM	SER-HIS-PHE-ASN-GLU-TYR-GLU

90% Homology Family

Leader:	43CA	CRYSTALLOGRAPHIC STRUCTURE OF THE ESTEROLYTIC AND AMIDOLYTIC 43C9 ANTIBODY WITH BOUND P-NITROPHENOL

PDB id	Binding data	Representative ligand
43CA	kd < 1.0 uM	NPO

90% Homology Family

Leader:	3ERY	DIFFERENT THERMODYNAMIC BINDING MECHANISMS AND PEPTIDE FINE

PDB id	Binding data	Representative ligand
3ERY		GLN-LEU-SER-PRO-PHE-PRO-PHE-ASP-LEU

90% Homology Family

Leader:	3DBX	STRUCTURE OF CHICKEN CD1-2 WITH BOUND FATTY ACID

PDB id	Binding data	Representative ligand
3DBX		PLM

90% Homology Family

Leader:	3CFD	PURPLE-FLUORESCENT ANTIBODY EP2-25C10 IN COMPLEX WITH ITS

PDB id	Binding data	Representative ligand
3CFD		SPB

90% Homology Family

Leader:	2ZPK	CRYSTAL STRUCTURE OF P20.1 FAB FRAGMENT IN COMPLEX WITH ITS

PDB id	Binding data	Representative ligand
2ZPK		PRO-ARG-GLY-TYR-PRO-GLY-GLN-VAL

90% Homology Family

Leader:	2UZI	CRYSTAL STRUCTURE OF HRAS(G12V)- ANTI-RAS FV COMPLEX

PDB id	Binding data	Representative ligand
2UZI		GTP

90% Homology Family

Leader:	2RDG	CRYSTAL STRUCTURE OF STAPHYLOCOCCAL SUPERANTIGEN-LIKE

PDB id	Binding data	Representative ligand
2RDG	Kd = 0.72 uM	NDG-FUC-SIA-GAL

90% Homology Family

Leader:	2PSM	CRYSTAL STRUCTURE OF INTERLEUKIN 15 IN COMPLEX WITH

PDB id	Binding data	Representative ligand
2PSM		BAM

90% Homology Family

Leader:	2PCP	ANTIBODY FAB COMPLEXED WITH PHENCYCLIDINE

PDB id	Binding data	Representative ligand
2PCP	kd = 2.0 nM	1PC

90% Homology Family

Leader:	2OMN	BENCE JONES KWR PROTEIN- IMMUNOGLOBULIN LIGHT CHAIN DIMER,

PDB id	Binding data	Representative ligand
2OMN		IPH

90% Homology Family

Leader:	2OK0	FAB ED10-DNA COMPLEX

PDB id	Binding data	Representative ligand
2OK0	Kd = 0.2 nM	DT--DC

90% Homology Family

Leader:	2O5Z	CRYSTAL STRUCTURE OF THE 1E9 LEUH47TRP/ARGH100TRP FAB 5-

PDB id	Binding data	Representative ligand
2O5Z	Kd = 110.0 mM	ANO

90% Homology Family

Leader:	2HXW	CRYSTAL STRUCTURE OF PEB3 FROM CAMPYLOBACTER JEJUNI

PDB id	Binding data	Representative ligand
2HXW		FLC

90% Homology Family

Leader:	2HVK	CRYSTAL STRUCTURE OF THE KCSA-FAB-TBA COMPLEX IN HIGH K+

PDB id	Binding data	Representative ligand
2HVK		TBA

90% Homology Family

Leader:	2HRP	ANTIGEN-ANTIBODY COMPLEX

PDB id	Binding data	Representative ligand
2HRP		MET-SER-LEU-PRO-GLY-ARG-TRP-LYS-PRO-LYS

90% Homology Family

Leader:	2DYP	CRYSTAL STRUCTURE OF LILRB2(LIR2/ILT4/CD85D) COMPLEXED WITH HLA-G

PDB id	Binding data	Representative ligand
2DYP		ARG-ILE-ILE-PRO-ARG-HIS-LEU-GLN-LEU

90% Homology Family

Leader:	2DWE	CRYSTAL STRUCTURE OF KCSA-FAB-TBA COMPLEX IN RB+

PDB id	Binding data	Representative ligand
2DWE		TBA

90% Homology Family

Leader:	2DDQ	CRYSTAL STRUCTURE OF THE FAB FRAGMENT OF A R310 ANTIBODY COMPLEXED WITH (R)-HNE-HISTIDINE ADDUCT

PDB id	Binding data	Representative ligand
2DDQ		HRB

90% Homology Family

Leader:	2CJU	CRYSTAL STRUCTURE OF THE TEPC15-VK45.1 ANTI-2 -PHENYL-5- OXAZOLONE NQ16-113.8 SCFV IN COMPLEX WITH PHOXGABA

PDB id	Binding data	Representative ligand
2CJU		PHX

90% Homology Family

Leader:	2C1P	FAB-FRAGMENT OF ENANTIOSELECTIVE ANTIBODY COMPLEXED WITH FINROZOLE

PDB id	Binding data	Representative ligand
2C1P		FNZ

90% Homology Family

Leader:	2BRS	EMBP HEPARIN COMPLEX

PDB id	Binding data	Representative ligand
2BRS		IDU-SGN

90% Homology Family

Leader:	2AZ5	CRYSTAL STRUCTURE OF TNF-ALPHA WITH A SMALL MOLECULE INHIBITOR

PDB id	Binding data	Representative ligand
2AZ5	IC50 = 22.0 uM	307

90% Homology Family

Leader:	1ZT1	CRYSTAL STRUCTURE OF CLASS I MHC H-2KK IN COMPLEX WITH AN OCTAPEPTIDE

PDB id	Binding data	Representative ligand
1ZT1		PHE-GLU-ALA-ASN-GLY-ASN-LEU-ILE

90% Homology Family

Leader:	1ZEA	STRUCTURE OF THE ANTI-CHOLERA TOXIN ANTIBODY FAB FRAGMENT

PDB id	Binding data	Representative ligand
1ZEA	Kd = 6.0 uM	DVA-DPR-GLY-DSN-DGN-DHI-DTY-DAS-DSN

90% Homology Family

Leader:	1YDP	1.9A CRYSTAL STRUCTURE OF HLA-G

PDB id	Binding data	Representative ligand
1YDP		ARG-ILE-ILE-PRO-ARG-HIS-LEU-GLN-LEU

90% Homology Family

Leader:	1Y0L	CATALYTIC ELIMINATION ANTIBODY 34E4 IN COMPLEX WITH HAPTEN

PDB id	Binding data	Representative ligand
1Y0L	Kd ~ 1.0 nM	HAN

90% Homology Family

Leader:	1XF2	STRUCTURE OF FAB DNA-1 COMPLEXED WITH DT3

PDB id	Binding data	Representative ligand
1XF2		T-T-T

90% Homology Family

Leader:	1X9Q	4M5.3 ANTI-FLUORESCEIN SINGLE CHAIN ANTIBODY FRAGMENT (SCFV)

PDB id	Binding data	Representative ligand
1X9Q	Kd = 0.27 pM	FLU

90% Homology Family

Leader:	1WZ1	CRYSTAL STRUCTURE OF THE FV FRAGMENT COMPLEXED WITH DANSYL- LYSINE

PDB id	Binding data	Representative ligand
1WZ1		DNS

90% Homology Family

Leader:	1W72	CRYSTAL STRUCTURE OF HLA-A1:MAGE-A1 IN COMPLEX WITH FAB-

PDB id	Binding data	Representative ligand
1W72	Kd = 14.0 nM	GLU-ALA-ASP-PRO-THR-GLY-HIS-SER-TYR

90% Homology Family

Leader:	1VPO	CRYSTAL STRUCTURE ANALYSIS OF THE ANTI-TESTOSTERONE FAB IN

PDB id	Binding data	Representative ligand
1VPO	Kd = 3.0 M	TES

90% Homology Family

Leader:	1UZ8	ANTI-LEWIS X FAB FRAGMENT IN COMPLEX WITH LEWIS X

PDB id	Binding data	Representative ligand
1UZ8	Kd = 10.75 uM	GAL-MAG-FUC

90% Homology Family

Leader:	1TMC	THE HTREE-DIMENSIONAL STRUCTURE OF A CLASS I MAJOR HISTOCOMPATIBILITY COMPLEX MOLECULE MISSING THE ALPHA3 DOMAIN OF THE HEAVY CHAIN

PDB id	Binding data	Representative ligand
1TMC		GLU-VAL-ALA-PRO-PRO-GLU-TYR-HIS-ARG-LYS

90% Homology Family

Leader:	1T66	THE STRUCTURE OF FAB WITH INTERMEDIATE AFFINITY FOR

PDB id	Binding data	Representative ligand
1T66		FLU

90% Homology Family

Leader:	1SVZ	CRYSTAL STRUCTURE OF THE SINGLE-CHAIN FV FRAGMENT 1696 IN

PDB id	Binding data	Representative ligand
1SVZ		PRO-GLN-PHE-SER-LEU-TRP-LYS-ARG

90% Homology Family

Leader:	1S3K	CRYSTAL STRUCTURE OF A HUMANIZED FAB (HU3S193) IN COMPLEX

PDB id	Binding data	Representative ligand
1S3K	Kd = 0.24 uM	FUC-GAL-NAG-FUC

90% Homology Family

Leader:	1QKZ	FAB FRAGMENT (MN14C11.6) IN COMPLEX WITH A PEPTIDE ANTIGEN DERIVED FROM NEISSERIA MENINGITIDIS P1.7 SEROSUBTYPE ANTIGEN AND DOMAIN II FROM STREPTOCOCCAL PROTEIN G

PDB id	Binding data	Representative ligand
1QKZ		ALA-ASN-GLY-GLY-ALA-SER-GLY-GLN-VAL-LYS

90% Homology Family

Leader:	1QD0	CAMELID HEAVY CHAIN VARIABLE DOMAINS PROVIDE EFFICIENT COMBINING SITES TO HAPTENS

PDB id	Binding data	Representative ligand
1QD0		RR6

90% Homology Family

Leader:	1Q0Y	ANTI-MORPHINE ANTIBODY 9B1 COMPLEXED WITH MORPHINE

PDB id	Binding data	Representative ligand
1Q0Y	Kd ~ 1.0 nM	MOI

90% Homology Family

Leader:	1ONQ	CRYSTAL STRUCTURE OF CD1A IN COMPLEX WITH A SULFATIDE

PDB id	Binding data	Representative ligand
1ONQ		SLF

90% Homology Family

Leader:	1O75	TP47, THE 47-KILODALTON LIPOPROTEIN OF TREPONEMA PALLIDUM

PDB id	Binding data	Representative ligand
1O75		PDX-PDX

90% Homology Family

Leader:	1NGP	N1G9 (IGG1-LAMBDA) FAB FRAGMENT COMPLEXED WITH (4-HYDROXY-3-NITROPHENYL) ACETATE

PDB id	Binding data	Representative ligand
1NGP		NPA

90% Homology Family

Leader:	1MI5	THE CRYSTAL STRUCTURE OF LC13 TCR IN COMPLEX WITH HLAB8-EBV PEPTIDE COMPLEX

PDB id	Binding data	Representative ligand
1MI5	kd ~ 10.0 uM	PHE-LEU-ARG-GLY-ARG-ALA-TYR-GLY-LEU

90% Homology Family

Leader:	1MFA	STRUCTURE OF A SINGLE-CHAIN FV FRAGMENT COMPLEXED WITH A CARBOHYDRATE ANTIGEN AT 1.7 ANGSTROMS RESOLUTION

PDB id	Binding data	Representative ligand
1MFA	kd = 9.1 uM	GAL-MMA-ABE

90% Homology Family

Leader:	1MEX	ANTIBODY CATALYSIS OF A BIMOLECULAR CYCLOADDITION REACTION

PDB id	Binding data	Representative ligand
1MEX		RAC

90% Homology Family

Leader:	1KJV	TAP-B-ASSOCIATED RAT MHC CLASS I MOLECULE

PDB id	Binding data	Representative ligand
1KJV		ASN-PRO-ARG-ALA-MET-GLN-ALA-LEU-LEU

90% Homology Family

Leader:	1KJM	TAP-A-ASSOCIATED RAT MHC CLASS I MOLECULE

PDB id	Binding data	Representative ligand
1KJM		ALA-GLN-PHE-SER-ALA-SER-ALA-SER-ARG

90% Homology Family

Leader:	1KEL	CATALYTIC ANTIBODY 28B4 FAB FRAGMENT COMPLEXED WITH HAPTEN (1-[N-4'-NITROBENZYL-N-4'-CARBOXYBUTYLAMINO ] METHYLPHOSPHONIC ACID)

PDB id	Binding data	Representative ligand
1KEL	kd = 52.0 nM	AAH

90% Homology Family

Leader:	1JOC	EEA1 HOMODIMER OF C-TERMINAL FYVE DOMAIN BOUND TO INOSITOL 1,3-DIPHOSPHATE

PDB id	Binding data	Representative ligand
1JOC	kd = 24.0 uM	ITP

90% Homology Family

Leader:	1JGU	STRUCTURAL BASIS FOR DISFAVORED ELIMINATION REACTION IN CATALYTIC ANTIBODY 1D4

PDB id	Binding data	Representative ligand
1JGU		HBC

90% Homology Family

Leader:	1JGL	CRYSTAL STRUCTURE OF IMMUNOGLOBULIN FAB FRAGMENT COMPLEXED WITH 17-BETA-ESTRADIOL

PDB id	Binding data	Representative ligand
1JGL	kd = 2.0 nM	EST

90% Homology Family

Leader:	1IND	HOW THE ANTI-(METAL CHELATE) ANTIBODY CHA255 IS SPECIFIC FOR THE METAL ION OF ITS ANTIGEN: X-RAY STRUCTURES FOR TWO FAB'(SLASH)HAPTEN COMPLEXES WITH DIFFERENT METALS IN THE CHELATE

PDB id	Binding data	Representative ligand
1IND	Ka = 1.10000005E10 M^-1	EOT

90% Homology Family

Leader:	1IM3	CRYSTAL STRUCTURE OF THE HUMAN CYTOMEGALOVIRUS PROTEIN US2 BOUND TO THE MHC CLASS I MOLECULE HLA-A2/TAX

PDB id	Binding data	Representative ligand
1IM3		LEU-LEU-PHE-GLY-TYR-PRO-VAL-TYR-VAL

90% Homology Family

Leader:	1IGJ	26-10 FAB:DIGOXIN COMPLEX-AFFINITY AND SPECIFICITY DUE TO SURFACE COMPLEMENTARITY

PDB id	Binding data	Representative ligand
1IGJ	kd = 0.1 nM	DGX

90% Homology Family

Leader:	1I7Z	ANTIBODY GNC92H2 BOUND TO LIGAND

PDB id	Binding data	Representative ligand
1I7Z	kd = 0.4 uM	COC

90% Homology Family

Leader:	1I3U	THREE-DIMENSIONAL STRUCTURE OF A LLAMA VHH DOMAIN COMPLEXED WITH THE DYE RR1

PDB id	Binding data	Representative ligand
1I3U		RR1

90% Homology Family

Leader:	1H8S	THREE-DIMENSIONAL STRUCTURE OF ANTI-AMPICILLIN SINGLE CHAIN FV FRAGMENT COMPLEXED WITH THE HAPTEN.

PDB id	Binding data	Representative ligand
1H8S	kd = 1.54 uM	AIC

90% Homology Family

Leader:	1H3T	CRYSTAL STRUCTURE OF THE HUMAN IGG1 FC-FRAGMENT ,GLYCOFORM (MN2F)2

PDB id	Binding data	Representative ligand
1H3T		BMA

90% Homology Family

Leader:	1GHQ	CR2-C3D COMPLEX STRUCTURE

PDB id	Binding data	Representative ligand
1GHQ		NAG

90% Homology Family

Leader:	1G1T	CRYSTAL STRUCTURE OF E-SELECTIN LECTIN/EGF DOMAINS COMPLEXED WITH SLEX

PDB id	Binding data	Representative ligand
1G1T		SIA-GAL-1NA-FUC

90% Homology Family

Leader:	1FLR	4-4-20 FAB FRAGMENT

PDB id	Binding data	Representative ligand
1FLR	kd = 0.1 nM	FLU

90% Homology Family

Leader:	1FE8	CRYSTAL STRUCTURE OF THE VON WILLEBRAND FACTOR A3 DOMAIN IN COMPLEX WITH A FAB FRAGMENT OF IGG RU5 THAT INHIBITS COLLAGEN BINDING

PDB id	Binding data	Representative ligand
1FE8		NAG

90% Homology Family

Leader:	1F4X	CRYSTAL STRUCTURE OF AN ANTI-CARBOHYDRATE ANTIBODY DIRECTED AGAINST VIBRIO CHOLERAE O1 IN COMPLEX WITH ANTIGEN

PDB id	Binding data	Representative ligand
1F4X	kd = 2.6 uM	MGS

90% Homology Family

Leader:	1F3D	CATALYTIC ANTIBODY 4B2 IN COMPLEX WITH ITS AMIDINIUM HAPTEN.

PDB id	Binding data	Representative ligand
1F3D		TPM

90% Homology Family

Leader:	1EAP	CRYSTAL STRUCTURE OF A CATALYTIC ANTIBODY WITH A SERINE PROTEASE ACTIVE SITE

PDB id	Binding data	Representative ligand
1EAP		HEP

90% Homology Family

Leader:	1DL7	THE STRUCTURAL BASIS OF REPERTOIRE SHIFT IN AN IMMUNE RESPONSE TO PHOSPHOCHOLINE

PDB id	Binding data	Representative ligand
1DL7	kd = 0.32 uM	NCH

90% Homology Family

Leader:	1D6V	CONFORMATION EFFECTS IN BIOLOGICAL CATALYSIS INTRODUCED BY OXY-COPE ANTIBODY MATURATION

PDB id	Binding data	Representative ligand
1D6V	kd = 670.0 nM	HOP

90% Homology Family

Leader:	1CT8	CATALYTIC ANTIBODY 7C8 COMPLEX

PDB id	Binding data	Representative ligand
1CT8	kd = 0.3 uM	TAA

90% Homology Family

Leader:	1CLY	IGG FAB (HUMAN IGG1, KAPPA) CHIMERIC FRAGMENT (CBR96) COMPLEXED WITH LEWIS Y NONOATE METHYL ESTER

PDB id	Binding data	Representative ligand
1CLY		FUC-GAL-NAG-FUC-NON

90% Homology Family

Leader:	1CE1	1.9A STRUCTURE OF THE THERAPEUTIC ANTIBODY CAMPATH -1H FAB IN COMPLEX WITH A SYNTHETIC PEPTIDE ANTIGEN

PDB id	Binding data	Representative ligand
1CE1		GLY-THR-SER-SER-PRO-SER-ALA-ASP

90% Homology Family

Leader:	1C9H	CRYSTAL STRUCTURE OF FKBP12.6 IN COMPLEX WITH RAPAMYCIN

PDB id	Binding data	Representative ligand
1C9H		RAP

90% Homology Family

Leader:	1C5C	DECARBOXYLASE CATALYTIC ANTIBODY 21D8-HAPTEN COMPLEX

PDB id	Binding data	Representative ligand
1C5C	kd = 110.0 nM	TK4

90% Homology Family

Leader:	1C1E	CRYSTAL STRUCTURE OF A DIELS-ALDERASE CATALYTIC ANTIBODY 1E9 IN COMPLEX WITH ITS HAPTEN

PDB id	Binding data	Representative ligand
1C1E		ENH

90% Homology Family

Leader:	1BD2	COMPLEX BETWEEN HUMAN T-CELL RECEPTOR B7, VIRAL PEPTIDE (TAX) AND MHC CLASS I MOLECULE HLA-A 0201

PDB id	Binding data	Representative ligand
1BD2		LEU-LEU-PHE-GLY-TYR-PRO-VAL-TYR-VAL

90% Homology Family

Leader:	1B09	HUMAN C-REACTIVE PROTEIN COMPLEXED WITH PHOSPHOCHOLINE

PDB id	Binding data	Representative ligand
1B09		PC

90% Homology Family

Leader:	1A4K	DIELS ALDER CATALYTIC ANTIBODY WITH TRANSITION STATE ANALOGUE

PDB id	Binding data	Representative ligand
1A4K	kd = 0.01 uM	FRA

90% Homology Family

Leader:	1A0Q	29G11 COMPLEXED WITH PHENYL [1-(1-N-SUCCINYLAMINO )PENTYL] PHOSPHONATE

PDB id	Binding data	Representative ligand
1A0Q	ki = 27.0 nM	HEP