Receptor
PDB id Resolution Class Description Source Keywords
1QJA 2 Å EC: 2.7.11.1 14-3-3 ZETA/PHOSPHOPEPTIDE COMPLEX (MODE 2) HOMO SAPIENS KINASE INHIBITOR/PEPTIDE COMPLEX (SIGNAL TRANSDUCTION-PEPTICOMPLEX 14-3-3 PHOSPHOPEPTIDE SIGNAL TRANSDUCTION KINASINHIBITOR-PEPTIDE COMPLEX
Ref.: STRUCTURAL ANALYSIS OF 14-3-3 PHOSPHOPEPTIDE COMPLE IDENTIFIES A DUAL ROLE FOR THE NUCLEAR EXPORT SIGNA 14-3-3 IN LIGAND BINDING MOL.CELL V. 4 153 1999
Ligand
Ligand Chain:Residue Validity Ligand Warnings Binding Data NGL Viewer Molecular Weight (Da) Formula SMILES
ARG LEU TYR HIS SEP LEU PRO ALA Q:3;
R:3;
 Valid;
Valid;
 none;
none;
 Kd = 416 nM
1020.1 n/a P(=O)...
View in 3D viewer
90% Homology Family
Leader
PDB id Resolution Class Description Source Keywords
4N84 2.5 Å EC: 2.7.11.1 CRYSTAL STRUCTURE OF 14-3-3ZETA IN COMPLEX WITH A 12-CARBON- CYCLIC PEPTIDE DERIVED FROM EXOS HOMO SAPIENS 14-3-3 ADAPTOR PROTEIN PROTEIN-PROTEIN INTERACTION CROSS-SIGNALING PROTEIN
Ref.: CONSTRAINED PEPTIDES WITH TARGET-ADAPTED CROSS-LINK INHIBITORS OF A PATHOGENIC PROTEIN-PROTEIN INTERACT ANGEW.CHEM.INT.ED.ENGL. V. 53 2489 2014
Members (10)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 133 families.
1 1QJB Ki = 416 nM ALA ARG SER HIS SEP TYR PRO ALA n/a n/a
2 6FNA - DWE C50 H66 N6 O20 P2 c1ccc(c(c1....
3 4N84 Kd = 41 nM GLY MKD LEU ASP MKD LEU ASP LEU ALA SER n/a n/a
4 1QJA Kd = 416 nM ARG LEU TYR HIS SEP LEU PRO ALA n/a n/a
5 6FNC - DWK C40 H48 N4 O15 P2 c1ccc(c(c1....
6 6FN9 ic50 = 284 uM DW8 C27 H38 N3 O10 P CCCNC(=O)C....
7 2C1N - ALA ARG LYS SEP THR GLY GLY LYS n/a n/a
8 2V7D Kd = 261 nM LYS SER ALA TPO THR THR VAL MET ASN PRO n/a n/a
9 6FNB - DWQ C59 H84 N6 O22 P2 c1ccc(c(c1....
10 3NKX Kd = 7.5 uM GLN ARG SER THR SEP THR PRO ASN VAL HIS n/a n/a
70% Homology Family (79)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 101 families.
1 6Y3W - LYS ARG ARG ARG LYS SEP CYS GLN ALA NH2 O85 n/a n/a
2 6HKB - ALA GLU GLY PHE PRO ALA TPO VAL n/a n/a
3 6FI5 Kd = 3 uM THR PRO SEP LEU PRO DAL 60H n/a n/a
4 5BTV Kd = 140 uM GLY SEP LEU GLY n/a n/a
5 6W0L - ALA ARG VAL SER MET ARG ARG MET SEP ASN n/a n/a
6 6XWD Kd = 2.18 uM ASN LYS ASN ALA ASN SEP SER PRO VAL n/a n/a
7 4Y32 ic50 = 90.1 uM ARG THR PRO SEP LEU PRO THR 49F n/a n/a
8 4Y5I ic50 = 301.3 uM ACE ARG THR PRO SEP LEU PRO THR PIP n/a n/a
9 6FBB - SER ARG SEP SER PRO n/a n/a
10 5N5W - 8OE C11 H8 Cl2 N2 O c1cc(ccc1N....
11 6FBY Kd = 9.3 uM ACE ARG THR PRO SEP LEU PRO GLY D4H n/a n/a
12 6Y3M - GLN SER TYR TPO VAL n/a n/a
13 6HHP Kd = 32 nM ALA GLU GLY PHE PRO ALA TPO VAL n/a n/a
14 4DHS - Y03 C14 H12 Cl2 N O5 P c1ccc(c(c1....
15 6Y3S - ASN ALA ARG SER ALA SEP PHE SER GLN GLY n/a n/a
16 6GHP - ACE LYS ARG ARG LYS SEP VAL n/a n/a
17 4DHO - Y09 C15 H16 N O6 P COc1cccc(c....
18 6Y8A - ARG SER LEU SEP ALA PRO GLY ASN n/a n/a
19 6Y8E - ARG SER PHE SEP GLU PRO PHE GLY n/a n/a
20 3IQV Kd = 6.6 uM FSC C36 H56 O12 C[C@@H]1[C....
21 4IEA Kd = 346 nM ARG SER ALA SEP GLU PRO SER LEU n/a n/a
22 6HN2 - ALA GLU GLY PHE PRO ALA TPO VAL n/a n/a
23 6Y58 Kd = 15.8 uM VAL TYR ARG SER LEU SEP PHE GLU n/a n/a
24 6FAW Kd = 2.7 uM ACE ARG THR PRO SEP LEU PRO GLY D3K n/a n/a
25 5N75 - ARG SER HIS SEP SER PRO ALA SER LEU GLN n/a n/a
26 4DHN - 0KC C13 H18 N O5 P c1ccc(c(c1....
27 3MHR - ARG ALA HIS SEP SER PRO ALA SER LEU GLN n/a n/a
28 4DHP - Y07 C15 H12 Cl F3 N O5 P c1ccc(c(c1....
29 3LW1 Kd = 16.3 uM PHE LYS TPO GLU GLY PRO ASP SER ASP n/a n/a
30 3SP5 Kd = 0.56 uM LYS ARG ARG LYS SEP VAL n/a n/a
31 4DHU - 0KH C14 H12 Cl2 N O5 P c1ccc(c(c1....
32 6HMT Kd = 92 nM ALA GLU GLY PHE PRO ALA TPO VAL n/a n/a
33 6Y1D - LYS ARG ARG ARG LYS SEP CYS GLN ALA NH2 n/a n/a
34 6XY5 - LYS ARG ARG ARG LYS SEP CYS GLN ALA O4E n/a n/a
35 3O8I - M1T C7 H14 O4 COCC(=O)CC....
36 6Y18 - LYS ARG ARG ARG LYS SEP CYS GLN ALA O68 n/a n/a
37 6TJM - NE5 C24 H16 N2 O8 c1ccc(cc1)....
38 5OEH - 9SZ C42 H32 O8 P2 c1ccc2c(c1....
39 4DHT - 0KG C14 H20 N O5 P c1ccc(c(c1....
40 6HKF - ALA GLU GLY PHE PRO ALA TPO VAL n/a n/a
41 6Y3O - ARG LYS LEU SEP LEU GLN GLU ARG n/a n/a
42 6Y8D - VAL GLU HIS SEP LEU ASP ASN LYS n/a n/a
43 5LU1 - ARG ARG ALA SEP ALA PRO LEU PRO n/a n/a
44 3IQJ Kd = 7.5 uM GLN ARG SER THR SEP THR PRO ASN VAL HIS n/a n/a
45 4FR3 Kd = 0.07 uM 0V4 C27 H44 O8 C[C@@H]1[C....
46 5HF3 Kd = 13.4 uM ACE ARG THR PRO SEP LEU PRO THR 60H n/a n/a
47 5N5R - NV1 C13 H20 N2 O Cc1cccc(c1....
48 4DHM - 0KB C15 H13 F3 N O5 P c1ccc(c(c1....
49 4DAT - SER SER PHE TYR PRO SEP ALA GLU GLY n/a n/a
50 6Y8B - TYR ASP LEU SEP LEU PRO PHE PRO n/a n/a
51 6FI4 Kd = 2.2 uM PRO SEP LEU PRO DVA 60H n/a n/a
52 3IQU - GLN ARG SER THR SEP THR n/a n/a
53 4DHQ - Y06 C14 H13 Cl N O5 P c1ccc(c(c1....
54 4DHR - Y04 C14 H13 Cl N O5 P c1ccc(c(c1....
55 4Y3B ic50 = 90.1 uM 49F C7 H15 N O COCC[C@@H]....
56 5N5T - SER HIS SEP SER PRO ALA SER LEU n/a n/a
57 6HMU - ALA GLU GLY PHE PRO ALA TPO VAL n/a n/a
58 6XXC - LYS ARG ARG ARG LYS SEP CYS GLN ALA O3W n/a n/a
59 6FBW Kd = 16.5 uM ARG THR PRO SEP LEU PRO GLY D4K n/a n/a
60 6FAV Kd = 4.7 uM ACE ARG THR PRO SEP LEU PRO GLY D3Q n/a n/a
61 5MXO - FSC C36 H56 O12 C[C@@H]1[C....
62 6TL3 - NJW C24 H17 N3 O7 c1ccc(cc1)....
63 6FAU Kd = 3.6 uM ACE ARG THR PRO SEP LEU PRO GLY D3W n/a n/a
64 1QJB Ki = 416 nM ALA ARG SER HIS SEP TYR PRO ALA n/a n/a
65 6FNA - DWE C50 H66 N6 O20 P2 c1ccc(c(c1....
66 4N84 Kd = 41 nM GLY MKD LEU ASP MKD LEU ASP LEU ALA SER n/a n/a
67 1QJA Kd = 416 nM ARG LEU TYR HIS SEP LEU PRO ALA n/a n/a
68 6FNC - DWK C40 H48 N4 O15 P2 c1ccc(c(c1....
69 6FN9 ic50 = 284 uM DW8 C27 H38 N3 O10 P CCCNC(=O)C....
70 2C1N - ALA ARG LYS SEP THR GLY GLY LYS n/a n/a
71 2V7D Kd = 261 nM LYS SER ALA TPO THR THR VAL MET ASN PRO n/a n/a
72 6FNB - DWQ C59 H84 N6 O22 P2 c1ccc(c(c1....
73 3NKX Kd = 7.5 uM GLN ARG SER THR SEP THR PRO ASN VAL HIS n/a n/a
74 2BR9 - ARG ARG GLN ARG SEP ALA PRO n/a n/a
75 2C63 - ARG ALA ILE SEP LEU PRO n/a n/a
76 5NWI Kd = 0.69 uM TYR PHE SER SEP ASN n/a n/a
77 1O9D Kd = 2.5 uM GLN SER TYR TPO VAL n/a n/a
78 5NWJ - HIS LEU TYR PHE SER SEP ASN n/a n/a
79 3E6Y Kd = 2.5 uM CW1 C34 H52 O12 C[C@@H]1[C....
50% Homology Family (79)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 70 families.
1 6Y3W - LYS ARG ARG ARG LYS SEP CYS GLN ALA NH2 O85 n/a n/a
2 6HKB - ALA GLU GLY PHE PRO ALA TPO VAL n/a n/a
3 6FI5 Kd = 3 uM THR PRO SEP LEU PRO DAL 60H n/a n/a
4 5BTV Kd = 140 uM GLY SEP LEU GLY n/a n/a
5 6W0L - ALA ARG VAL SER MET ARG ARG MET SEP ASN n/a n/a
6 6XWD Kd = 2.18 uM ASN LYS ASN ALA ASN SEP SER PRO VAL n/a n/a
7 4Y32 ic50 = 90.1 uM ARG THR PRO SEP LEU PRO THR 49F n/a n/a
8 4Y5I ic50 = 301.3 uM ACE ARG THR PRO SEP LEU PRO THR PIP n/a n/a
9 6FBB - SER ARG SEP SER PRO n/a n/a
10 5N5W - 8OE C11 H8 Cl2 N2 O c1cc(ccc1N....
11 6FBY Kd = 9.3 uM ACE ARG THR PRO SEP LEU PRO GLY D4H n/a n/a
12 6Y3M - GLN SER TYR TPO VAL n/a n/a
13 6HHP Kd = 32 nM ALA GLU GLY PHE PRO ALA TPO VAL n/a n/a
14 4DHS - Y03 C14 H12 Cl2 N O5 P c1ccc(c(c1....
15 6Y3S - ASN ALA ARG SER ALA SEP PHE SER GLN GLY n/a n/a
16 6GHP - ACE LYS ARG ARG LYS SEP VAL n/a n/a
17 4DHO - Y09 C15 H16 N O6 P COc1cccc(c....
18 6Y8A - ARG SER LEU SEP ALA PRO GLY ASN n/a n/a
19 6Y8E - ARG SER PHE SEP GLU PRO PHE GLY n/a n/a
20 3IQV Kd = 6.6 uM FSC C36 H56 O12 C[C@@H]1[C....
21 4IEA Kd = 346 nM ARG SER ALA SEP GLU PRO SER LEU n/a n/a
22 6HN2 - ALA GLU GLY PHE PRO ALA TPO VAL n/a n/a
23 6Y58 Kd = 15.8 uM VAL TYR ARG SER LEU SEP PHE GLU n/a n/a
24 6FAW Kd = 2.7 uM ACE ARG THR PRO SEP LEU PRO GLY D3K n/a n/a
25 5N75 - ARG SER HIS SEP SER PRO ALA SER LEU GLN n/a n/a
26 4DHN - 0KC C13 H18 N O5 P c1ccc(c(c1....
27 3MHR - ARG ALA HIS SEP SER PRO ALA SER LEU GLN n/a n/a
28 4DHP - Y07 C15 H12 Cl F3 N O5 P c1ccc(c(c1....
29 3LW1 Kd = 16.3 uM PHE LYS TPO GLU GLY PRO ASP SER ASP n/a n/a
30 3SP5 Kd = 0.56 uM LYS ARG ARG LYS SEP VAL n/a n/a
31 4DHU - 0KH C14 H12 Cl2 N O5 P c1ccc(c(c1....
32 6HMT Kd = 92 nM ALA GLU GLY PHE PRO ALA TPO VAL n/a n/a
33 6Y1D - LYS ARG ARG ARG LYS SEP CYS GLN ALA NH2 n/a n/a
34 6XY5 - LYS ARG ARG ARG LYS SEP CYS GLN ALA O4E n/a n/a
35 3O8I - M1T C7 H14 O4 COCC(=O)CC....
36 6Y18 - LYS ARG ARG ARG LYS SEP CYS GLN ALA O68 n/a n/a
37 6TJM - NE5 C24 H16 N2 O8 c1ccc(cc1)....
38 5OEH - 9SZ C42 H32 O8 P2 c1ccc2c(c1....
39 4DHT - 0KG C14 H20 N O5 P c1ccc(c(c1....
40 6HKF - ALA GLU GLY PHE PRO ALA TPO VAL n/a n/a
41 6Y3O - ARG LYS LEU SEP LEU GLN GLU ARG n/a n/a
42 6Y8D - VAL GLU HIS SEP LEU ASP ASN LYS n/a n/a
43 5LU1 - ARG ARG ALA SEP ALA PRO LEU PRO n/a n/a
44 3IQJ Kd = 7.5 uM GLN ARG SER THR SEP THR PRO ASN VAL HIS n/a n/a
45 4FR3 Kd = 0.07 uM 0V4 C27 H44 O8 C[C@@H]1[C....
46 5HF3 Kd = 13.4 uM ACE ARG THR PRO SEP LEU PRO THR 60H n/a n/a
47 5N5R - NV1 C13 H20 N2 O Cc1cccc(c1....
48 4DHM - 0KB C15 H13 F3 N O5 P c1ccc(c(c1....
49 4DAT - SER SER PHE TYR PRO SEP ALA GLU GLY n/a n/a
50 6Y8B - TYR ASP LEU SEP LEU PRO PHE PRO n/a n/a
51 6FI4 Kd = 2.2 uM PRO SEP LEU PRO DVA 60H n/a n/a
52 3IQU - GLN ARG SER THR SEP THR n/a n/a
53 4DHQ - Y06 C14 H13 Cl N O5 P c1ccc(c(c1....
54 4DHR - Y04 C14 H13 Cl N O5 P c1ccc(c(c1....
55 4Y3B ic50 = 90.1 uM 49F C7 H15 N O COCC[C@@H]....
56 5N5T - SER HIS SEP SER PRO ALA SER LEU n/a n/a
57 6HMU - ALA GLU GLY PHE PRO ALA TPO VAL n/a n/a
58 6XXC - LYS ARG ARG ARG LYS SEP CYS GLN ALA O3W n/a n/a
59 6FBW Kd = 16.5 uM ARG THR PRO SEP LEU PRO GLY D4K n/a n/a
60 6FAV Kd = 4.7 uM ACE ARG THR PRO SEP LEU PRO GLY D3Q n/a n/a
61 5MXO - FSC C36 H56 O12 C[C@@H]1[C....
62 6TL3 - NJW C24 H17 N3 O7 c1ccc(cc1)....
63 6FAU Kd = 3.6 uM ACE ARG THR PRO SEP LEU PRO GLY D3W n/a n/a
64 1QJB Ki = 416 nM ALA ARG SER HIS SEP TYR PRO ALA n/a n/a
65 6FNA - DWE C50 H66 N6 O20 P2 c1ccc(c(c1....
66 4N84 Kd = 41 nM GLY MKD LEU ASP MKD LEU ASP LEU ALA SER n/a n/a
67 1QJA Kd = 416 nM ARG LEU TYR HIS SEP LEU PRO ALA n/a n/a
68 6FNC - DWK C40 H48 N4 O15 P2 c1ccc(c(c1....
69 6FN9 ic50 = 284 uM DW8 C27 H38 N3 O10 P CCCNC(=O)C....
70 2C1N - ALA ARG LYS SEP THR GLY GLY LYS n/a n/a
71 2V7D Kd = 261 nM LYS SER ALA TPO THR THR VAL MET ASN PRO n/a n/a
72 6FNB - DWQ C59 H84 N6 O22 P2 c1ccc(c(c1....
73 3NKX Kd = 7.5 uM GLN ARG SER THR SEP THR PRO ASN VAL HIS n/a n/a
74 2BR9 - ARG ARG GLN ARG SEP ALA PRO n/a n/a
75 2C63 - ARG ALA ILE SEP LEU PRO n/a n/a
76 5NWI Kd = 0.69 uM TYR PHE SER SEP ASN n/a n/a
77 1O9D Kd = 2.5 uM GLN SER TYR TPO VAL n/a n/a
78 5NWJ - HIS LEU TYR PHE SER SEP ASN n/a n/a
79 3E6Y Kd = 2.5 uM CW1 C34 H52 O12 C[C@@H]1[C....
Polypharmacology
Similar Ligands (2D)
Ligand no: 1; Ligand: ARG LEU TYR HIS SEP LEU PRO ALA; Similar ligands found: 125
No: Ligand ECFP6 Tc MDL keys Tc
1 ARG LEU TYR HIS SEP LEU PRO ALA 1 1
2 ALA ARG SER HIS SEP TYR PRO ALA 0.730263 0.961538
3 ARG SER HIS SEP SER PRO ALA SER LEU GLN 0.652439 0.911392
4 ARG THR PRO SEP LEU PRO THR 49F 0.573333 0.909091
5 ARG THR PRO SEP LEU PRO THR 0.573333 0.909091
6 ARG LEU TYR GLN ASN PRO THR THR TYR ILE 0.552941 0.851852
7 TYR HIS SEP VAL VAL ARG TYR ALA 0.546584 0.884615
8 SER HIS SEP SER PRO ALA SER LEU GLN 0.541667 0.860759
9 PHE LEU PRO HIS ALY TYR ASP VAL LYS LEU 0.531073 0.775
10 ARG ALA HIS SEP SER PRO ALA SER LEU GLN 0.52795 0.860759
11 HIS SER ILE THR TYR LEU LEU PRO VAL 0.526627 0.825
12 ARG ILE ILE PRO ARG HIS LEU GLN LEU 0.52381 0.775
13 TYR ASP LEU SEP LEU PRO PHE PRO 0.520958 0.8625
14 ARG SER LEU SEP ALA PRO GLY ASN 0.519231 0.8375
15 SER HIS SEP SER PRO ALA SER LEU 0.515337 0.871795
16 ARG SEP PRO VAL PHE SER 0.512195 0.883117
17 ARG THR PHE SER PRO THR TYR GLY LEU 0.508772 0.839506
18 ARG ILE PRO SER TYR ARG TYR ARG TYR 0.50625 0.85
19 ARG ARG ALA SEP ALA PRO LEU PRO 0.503106 0.871795
20 ALA LEU PRO HIS ALA ILE LEU ARG LEU 0.502959 0.772152
21 PHE PRO ARG PRO TRP LEU HIS GLY LEU 0.497297 0.790123
22 ARG TYR PRO LEU THR PHE GLY TRP 0.494624 0.829268
23 LYS PRO ILE VAL VAL LEU HIS GLY TYR 0.494318 0.775
24 ARG SER ALA SEP GLU PRO SER LEU 0.491018 0.85
25 HIS LEU TYR PHE SER SEP ASN 0.487654 0.777778
26 LEU PRO PHE GLU LEU ARG GLY HIS LEU VAL 0.483333 0.797468
27 HIS HIS ALA SER PRO ARG LYS 0.47929 0.818182
28 SER LEU PHE HIS 22G THR PRO 0.477528 0.825
29 ARG TYR PRO LEU THR PHE GLY TRP CYS PHE 0.477157 0.841463
30 TYR TYR SER ILE ALA PRO HIS SER ILE 0.476471 0.802469
31 ARG TYR PRO LEU THR LEU GLY TRP CYS PHE 0.472081 0.831325
32 TYR TYR SER ILE ILE PRO HIS SER ILE 0.470238 0.802469
33 ARG MET PHE PRO ASN ALA PRO TYR LEU 0.469613 0.790698
34 ARG ARG LEU PRO ILE PHE SER ARG LEU 0.467836 0.8
35 TYR LEU LYS GLU PRO VAL HIS GLY VAL 0.466667 0.78481
36 ARG THR TYR SEP GLY PRO MET ASN LYS VAL 0.466321 0.892857
37 N7P THR SEP PRO SER TYR SET 0.462963 0.8375
38 ARG THR PRO SEP LEU PRO GLY D4K 0.462366 0.9375
39 ARG ARG LEU LEU ARG GLY HIS ASN GLN TYR 0.461988 0.775
40 LYS ARG ARG ARG HIS PRO SER 0.460123 0.792208
41 LYS ARG ARG ARG HIS PRO SER GLY 0.457831 0.78481
42 ARG GLN ALA SEP ILE GLU LEU PRO SER MET 0.457447 0.8
43 ARG PHE PRO LEU THR PHE GLY TRP 0.456989 0.804878
44 LEU GLN ARG VAL LEU SEP ALA PRO PHE 0.45614 0.860759
45 DHI PRO PHE HIS LEU LEU VAL TYR 0.455056 0.772152
46 LYS LEU TYR GLN ASN PRO THR THR TYR ILE 0.455056 0.777778
47 ASN ASP TRP LEU LEU PRO SER TYR 0.453039 0.792683
48 DTY ILE ARG LEU LPD 0.45283 0.807692
49 PRO PRO THR LEU HIS GLU LEU TYR ASP LEU 0.452514 0.8125
50 ACE ARG THR PRO SEP LEU PRO THR PIP 0.449102 0.8875
51 PIV HIS PRO PHE HIS LPL TYR TYR SER 0.448087 0.777778
52 ARG HIS ARG MLZ VAL LEU ARG ASP ASN TYR 0.447514 0.738095
53 ALA TRP ARG HIS PRO GLN PHE GLY GLY 0.447368 0.740741
54 SER SER TYR ARG ARG PRO VAL GLY ILE 0.445714 0.85
55 ARG ARG GLU VAL HIS THR TYR TYR 0.444444 0.753086
56 VAL PRO LEU ARG PRO MET THR TYR 0.443182 0.807229
57 GLN VAL PRO LEU ARG PRO MET THR TYR LYS 0.442708 0.797619
58 GLU ALA ASP PRO THR GLY HIS SER TYR 0.442623 0.8
59 LYS TYR TYR SER ILE ILE PRO HIS SER ILE 0.439306 0.802469
60 ARG PRO MET THR TYR LYS GLY ALA LEU 0.439153 0.776471
61 ASP TYR ASN PRO TYR LEU LEU PHE LEU LYS 0.438596 0.765432
62 GLY HIS ARG PRO 0.437086 0.721519
63 ACE ARG THR PRO SEP LEU PRO THR 60H 0.435754 0.924051
64 ARG PHE PRO LEU THR PHE GLY TRP CYS PHE 0.434343 0.807229
65 LYS VAL ALA PRO PRO ILE PRO HIS ARG 0.434066 0.772152
66 SER SER PHE TYR PRO SEP ALA GLU GLY 0.432749 0.8125
67 TYR PRO LYS ARG ILE ALA 0.431953 0.797468
68 LEU LEU PHE GLY LYS PRO VAL TYR VAL 0.431818 0.707317
69 ASN ARG PRO VAL TYR ILE PRO ARG PRO PRO 0.431034 0.833333
70 TYR SEP PRO THR SEP PRO SER 0.43038 0.835443
71 GLY LEU LEU GLY SEP PRO VAL ARG ALA 0.430233 0.835443
72 GLU TYR LEU GLY LEU ASP VAL PRO VAL 0.430233 0.734177
73 PRO ARG PRO ILE LEU LEU PRO TRP ARG NH2 0.430168 0.78481
74 SER ARG ASP HIS SER ARG THR PRO MET 0.429348 0.785714
75 ALA PHE ARG ILE PRO LEU THR ARG 0.428571 0.8
76 PRO SER TYR SEP PRO THR SEP PRO SER 0.428571 0.835443
77 ARG VAL ALA SEP PRO THR SER GLY VAL 0.427746 0.8375
78 TYR LEU ASP SEP GLY ILE HIS SER GLY ALA 0.426966 0.792683
79 LEU LEU PHE GLY PHE PRO VAL TYR VAL 0.425287 0.725
80 SER HIS PRO ARG PRO ILE ARG VAL 0.425287 0.825
81 LEU LEU PHE GLY TYR PRO VAL TYR VAL 0.425287 0.725
82 ARG LEU PRO ALA LYS ALA PRO LEU LEU 0.42515 0.746835
83 ARG PRO PRO GLY PHE SER PRO PHE ALA 0.423729 0.797468
84 SER ILE TYR PHE TPO PRO GLU LEU TYR ASP 0.42328 0.841463
85 ACE ARG THR PRO SEP LEU PRO GLY D3Q 0.422111 0.925926
86 TYR PRO ASN VAL ASN ILE HIS ASN PHE 0.41989 0.768293
87 ARG GLY TYR LEU TYR GLN GLY LEU 0.419753 0.6625
88 VAL TYR ILE HIS PRO PHE 0.419753 0.782051
89 ILE ARG TYR PRO LYS THR PHE GLY TRP 0.418719 0.807229
90 MET TYR TRP TYR PRO TYR 0.418605 0.678571
91 HIS SER LEU PHE HIS PUK THR PRO 0.418478 0.8
92 ACE PRO LEU HIS SER TPO ALA NH2 0.418182 0.8625
93 SER THR GLY GLY VAL M3L LYS PRO HIS ARG 0.417085 0.809524
94 MET VAL TRP GLY PRO ASP PRO LEU TYR VAL 0.416244 0.729412
95 PRO PRO ARG PRO ILE TYR ASN ARG ASN 0.41573 0.825
96 LYS LEU PRO ALA GLN PHE TYR ILE LEU 0.413043 0.728395
97 ILE GLY PRO GLY ARG ALA PHE TYR ALA 0.412088 0.777778
98 THR PRO SEP LEU PRO GLY D4H 0.411429 0.839506
99 ARG HIS ARG MLY VAL LEU ARG ASP TYR 0.411111 0.783133
100 ILE GLY PRO GLY ARG ALA PHE TYR THR 0.410811 0.790123
101 GLU LEU PRO PRO VAL LYS ILE HIS CYS 0.410526 0.703704
102 ARG ARG ARG TRP HIS ARG TRP ARG LEU 0.409639 0.7
103 GLY HIS ARG PRO NH2 0.409091 0.717949
104 ILE PRO ALA TYR GLY VAL LEU THR ILE 0.409091 0.728395
105 LEU TYR ALA SER PRO GLN LEU GLU GLY PHE 0.408602 0.7625
106 HCI PRO LEU HIS SER TPO ALA NH2 0.407821 0.898734
107 ASP VAL GLN THR GLY ARG ARG PRO TYR GLU 0.407609 0.825
108 ACE PRO LEU HIS SER TPO 0.407407 0.839506
109 THR PRO SEP LEU PRO DAL 60H 0.407186 0.848101
110 ARG ALA ILE SEP LEU PRO 0.406897 0.759494
111 BOC HIS PRO PHE HIS STA LEU PHE 0.40678 0.780488
112 ILE LEU LYS GLU PRO VAL HIS GLY VAL 0.406593 0.7
113 GLY TYR GLN ASP TYR GLU PRO GLU ALA 0.40625 0.683544
114 TYR PRO TYR ASP VAL PRO ASP TYR ALA 0.406061 0.7375
115 MET SER LEU PRO GLY ARG TRP LYS PRO LYS 0.403941 0.788235
116 ALA CYS SEP PRO GLN PHE GLY 0.403509 0.75
117 ACE ARG THR PRO SEP LEU PRO GLY D4H 0.403061 0.9125
118 LEU ASP PRO ARG 0.402597 0.721519
119 ACE LEU TYR ALA SER SER ASN PRO ALA PTR 0.402235 0.853659
120 THR PRO SEP LEU PRO GLY D3W 0.402235 0.843373
121 VAL MET ALA PRO ARG THR LEU PHE LEU 0.402174 0.75
122 ASN ALA LEU LEU ARG TYR LEU LEU ASP 0.401235 0.675
123 ACE PRO LEU HIS SER TPO MET NH2 0.401163 0.831325
124 MET TRP ARG PRO TRP 0.40113 0.710843
125 LYS ILE LEU HIS ARG LEU LEU GLN ASP 0.40113 0.6875
Similar Ligands (3D)
Ligand no: 1; Ligand: ARG LEU TYR HIS SEP LEU PRO ALA; Similar ligands found: 0
No: Ligand Similarity coefficient
Similar Binding Sites (Proteins are less than 50% similar to leader) APoc FAQ
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